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BOLD signal physiology: Models and applications


BOLD signal physiology: Models and applications

Gauthier, Claudine J. and Fan, A.P. (2018) BOLD signal physiology: Models and applications. NeuroImage . (In Press)

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The BOLD contrast mechanism has a complex relationship with functional brain activity, oxygen metabolism, and neurovascular factors. Accurate interpretation of the BOLD signal for neuroscience and clinical applications necessitates a clear understanding of the sources of BOLD contrast and its relationship to underlying physiology. This review describes the physiological components that contribute to the BOLD signal and the steady-state calibrated BOLD models that enable quantification of functional changes with a separate challenge paradigm. The principles derived from these biophysical models are then used to interpret BOLD measurements in different neurological disorders in the presence of confounding vascular factors related to disease.

Divisions:Concordia University > Faculty of Arts and Science > Physics
Item Type:Article
Authors:Gauthier, Claudine J. and Fan, A.P.
Journal or Publication:NeuroImage
Date:13 March 2018
  • GE Healthcare
  • Stanford Neuroscience Institute Interdisciplinary Scholar Award
  • Heart and Stroke Foundation of Canada
Digital Object Identifier (DOI):10.1016/j.neuroimage.2018.03.018
ID Code:983571
Deposited On:16 Mar 2018 19:04
Last Modified:13 Mar 2019 00:00


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