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Serotonin 5-HT1A Receptor-Mediated Reduction of Excitatory Synaptic Transmission in Layers Ii/Iii of The PARASUBICULUM

Title:

Serotonin 5-HT1A Receptor-Mediated Reduction of Excitatory Synaptic Transmission in Layers Ii/Iii of The PARASUBICULUM

Carter, Francis and Chapman, C. Andrew (2019) Serotonin 5-HT1A Receptor-Mediated Reduction of Excitatory Synaptic Transmission in Layers Ii/Iii of The PARASUBICULUM. Neuroscience . ISSN 03064522 (In Press)

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Official URL: http://dx.doi.org/10.1016/j.neuroscience.2019.03.0...

Abstract

Serotonin (5-HT) has important effects on cognitive function within the hippocampal region where it modulates membrane potential and excitatory and inhibitory synaptic transmission. Here, we investigated how 5-HT modulates excitatory synaptic strength in layers II/III of the parasubiculum in rat brain slices. Bath-application of 1 or 10 μM 5-HT resulted in a strong, dose-dependent, and reversible reduction in the amplitude of field excitatory postsynaptic potentials (fEPSPs) recorded in the parasubiculum. The 5-HT reuptake blocker citalopram (10 μM) also reduced fEPSP amplitudes, indicating that 5-HT released within the slice inhibits synaptic transmission. The reduction of fEPSPs induced by 5-HT was blocked by the 5-HT1A receptor blocker NAN-190 (10 μM), but not by the 5-HT7 receptor blocker SB-269970 (10 μM). Moreover, the 5-HT1A agonist 8-OH-DPAT induced a reduction of fEPSP amplitude similar to that induced by 5-HT. The reduction was prevented by the 5-HT1A receptor blocker NAN-190. The reduction in fEPSPs induced by either 5-HT or by 8-OH-DPAT was accompanied by an increase in paired-pulse ratio, suggesting that it is due mainly to reduced glutamate release. Our data suggest that the effects of serotonin on cognitive function may depend in part upon a 5-HT1A-mediated reduction of excitatory synaptic transmission in the parasubiculum. This may also affect synaptic processing in the entorhinal cortex, which receives the major output projection of the parasubiculum.

Divisions:Concordia University > Research Units > Centre for Studies in Behavioural Neurobiology
Item Type:Article
Refereed:Yes
Authors:Carter, Francis and Chapman, C. Andrew
Journal or Publication:Neuroscience
Date:19 March 2019
Funders:
  • Natural Sciences and Engineering Research Council of Canada (NSERC)
  • Fonds de recherche du Québec – Santé (FRQS)
Digital Object Identifier (DOI):10.1016/j.neuroscience.2019.03.024
Keywords:Parasubiculum; EPSP; rat; serotonin; 5-HT1A receptor
ID Code:985115
Deposited By: MICHAEL BIRON
Deposited On:08 Apr 2019 15:52
Last Modified:08 Apr 2019 15:52

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