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Comparing ABA, AAB, and ABC Renewal of Appetitive Pavlovian Conditioned Responding in Alcohol- and Sucrose-Trained Male Rats

Title:

Comparing ABA, AAB, and ABC Renewal of Appetitive Pavlovian Conditioned Responding in Alcohol- and Sucrose-Trained Male Rats

Khoo, Shaun Yon-Seng ORCID: https://orcid.org/0000-0002-0972-3788, Sciascia, Joanna Marie, Brown, Alexa and Chaudhri, Nadia ORCID: https://orcid.org/0000-0003-4217-4044 (2020) Comparing ABA, AAB, and ABC Renewal of Appetitive Pavlovian Conditioned Responding in Alcohol- and Sucrose-Trained Male Rats. Frontiers in Behavioral Neuroscience, 14 . p. 5. ISSN 1662-5153

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Official URL: https://doi.org/10.3389/fnbeh.2020.00005

Abstract

Conditioned responding can be renewed by re-exposure to the conditioning context following extinction in a different context (ABA renewal) or by removal from the extinction context (AAB or ABC renewal). ABA renewal is robust in Pavlovian and operant conditioning paradigms. However, fewer studies have investigated AAB and ABC renewal of appetitive conditioning, and those that did predominantly used operant conditioning tasks. Renewal has theoretical relevance for extinction and for exposure-based treatments for substance use disorders that aim to extinguish reactivity to drug-predictive cues. We therefore investigated ABA, AAB, and ABC renewal of Pavlovian conditioned responding to cues that predicted either alcohol or sucrose. Male, Long-Evans rats (Charles River) were exposed to either 15% ethanol (Study 1: “alcohol”) or 10% sucrose (Study 2: “sucrose”) in their home cages. Next, they were trained to discriminate between two auditory stimuli (white noise and clicker; 10 s) in conditioning chambers equipped with distinct olfactory, visual, and tactile contextual stimuli (context A). One conditioned stimulus (CS+) was paired with fluid delivery (0.2 ml/CS+; 3.2 ml/session; alcohol or sucrose in separate experiments), and the second CS (CS−) was not. In all sessions (conditioning, extinction, and test), each CS was presented 16 times/session on a variable-time 67-s schedule, and entries into the fluid port were recorded. CS+ port entries were then extinguished by withholding fluid delivery either in context A or in a second, different context (context B). Next, we assessed ABA, AAB, and ABC renewal in the absence of fluid delivery. During extinction, CS+ port entries were initially elevated in context A relative to context B. ABA renewal of CS+ port entries occurred in both alcohol- and sucrose-trained rats. ABC renewal approached statistical significance when data from both experiments were combined. No AAB renewal was observed, and, in fact, alcohol-trained rats showed AAB suppression. These results corroborate the reliability of ABA renewal and suggest that ABC renewal is a modest effect that may require greater statistical power to detect. From a treatment perspective, the lack of AAB renewal suggests that exposure-based treatments for substance use disorders might benefit from implementation in real-world, drug-use contexts.

Divisions:Concordia University > Research Units > Centre for Studies in Behavioural Neurobiology
Item Type:Article
Refereed:Yes
Authors:Khoo, Shaun Yon-Seng and Sciascia, Joanna Marie and Brown, Alexa and Chaudhri, Nadia
Journal or Publication:Frontiers in Behavioral Neuroscience
Date:13 February 2020
Funders:
  • Canadian Institutes of Health Research
  • Natural Sciences and Engineering Research Council
  • Fonds de la Recherche du Québec—Santé
  • Fonds de Recherche du Quebec Nature et Technologies
  • Concordia University
Digital Object Identifier (DOI):10.3389/fnbeh.2020.00005
Keywords:renewal, context, reinstatement, relapse, alcohol, sucrose, reward, Pavlovian conditioning
ID Code:986435
Deposited By: SHAUN YON-SENG KHOO
Deposited On:13 Feb 2020 20:21
Last Modified:13 Feb 2020 20:21
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