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The myriad roles of Anillin during cytokinesis


The myriad roles of Anillin during cytokinesis

Piekny, Alisa J and Maddox, Amy Shaub (2010) The myriad roles of Anillin during cytokinesis. Seminars in Cell and Developmental Biology, 21 (9). pp. 881-891. ISSN 1084-9521

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Official URL: http://dx.doi.org/10.1016/j.semcdb.2010.08.002


Anillin is a highly conserved multidomain protein that interacts with cytoskeletal components as well as their regulators. Throughout phylogeny, Anillins contribute to cytokinesis, the cell shape change that occurs at the end of meiosis and mitosis to separate a cell into daughter cells. Failed cytokinesis results in binucleation, which can lead to genomic instability. Study of Anillin in several model organisms has provided us with insight into how the cytoskeleton is coordinated to ensure that cytokinesis occurs with high fidelity. Here we review Anillin’s interacting partners and the relevance of these interactions in vivo. We also discuss questions of how these interactions are coordinated, and finally provide some perspective regarding Anillin’s role in cancer.

Divisions:Concordia University > Faculty of Arts and Science > Biology
Item Type:Article
Authors:Piekny, Alisa J and Maddox, Amy Shaub
Journal or Publication:Seminars in Cell and Developmental Biology
Date:December 2010
Digital Object Identifier (DOI):10.1016/j.semcdb.2010.08.002
Keywords:cytoskeleton; cytokinesis; Rho; F-actin; cellularization
ID Code:7014
Deposited By: ALISA PIEKNY
Deposited On:18 Jan 2011 19:31
Last Modified:18 Jan 2018 17:29


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