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Cyclin Cln3p Links G1 Progression to Hyphal and Pseudohyphal Development in Candida albicans


Cyclin Cln3p Links G1 Progression to Hyphal and Pseudohyphal Development in Candida albicans

Bachewich, Catherine and Whiteway, Malcolm (2005) Cyclin Cln3p Links G1 Progression to Hyphal and Pseudohyphal Development in Candida albicans. Eukaryotic Cell, 4 (1). pp. 95-102. ISSN 1535-9778

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Official URL: http://dx.doi.org/10.1128/EC.4.1.95-102.2005

Divisions:Concordia University > Faculty of Arts and Science > Biology
Item Type:Article
Authors:Bachewich, Catherine and Whiteway, Malcolm
Journal or Publication:Eukaryotic Cell
Date:January 2005
Digital Object Identifier (DOI):10.1128/EC.4.1.95-102.2005
ID Code:7582
Deposited By: Danielle Dennie
Deposited On:11 May 2011 21:27
Last Modified:18 Jan 2018 17:31


Bachewich, C., D. Y. Thomas, and M. Whiteway. 2003. Depletion of a polo-like kinase in Candida albicans activates cyclase-dependent hyphal-like growth. Mol. Biol. Cell 14:2163-2180

Bai, C., N. Ramanan, Y. M. Wang, and Y. Wang. 2002. Spindle assembly checkpoint component CaMad2p is indispensable for Candida albicans survival and virulence in mice. Mol. Microbiol. 45:31-44

Belli, G., E. Gari, M. Aldea, and E. Herrero. 2001. Osmotic stress causes a G1 cell cycle delay and downregulation of Cln3/Cdc28 activity in Saccharomyces cerevisiae. Mol. Microbiol. 39:1022-1035

Berman, J., and P. E. Sudbery. 2002. Candida albicans: a molecular revolution built on lessons from budding yeast. Nat. Rev. Genet. 3:918-930

Care, R. S., J. Trevethick, K. M. Binley, and P. E. Sudbery. 1999. The MET3 promoter: a new tool for Candida albicans molecular genetics. Mol. Microbiol. 34:792-798

Chapa y Lazo, B. S. Bates, and P. Sudbery. 2005. The G1 cyclin Cln3 regulates morphogenesis in Candida albicans. Eukaryot. Cell 4:90-94

Costanzo, M., J. L. Nishikawa, X. Tang, J. S. Millman, O. Schub, K. Breitkreuz, D. Dewar, I. Rupes, B. Andrews, and M. Tyers. 2004. CDK activity antagonizes Whi5, an inhibitor of G1/S transcription in yeast. Cell 117:899-913

Cross, F. R. 1988. DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae. Mol. Cell. Biol. 8:4675-4684

Danaie, P., M. Altmann, M. N. Hall, H. Trachsel, and S. B. Helliwell. 1999. CLN3 expression is sufficient to restore G1-to-S-phase progression in Saccharomyces cerevisiae mutants defective in translation initiation factor eIF4E. Biochem. J. 340(Pt 1):135-141

Davis, D. A., V. M. Bruno, L. Loza, S. G. Filler, and A. P. Mitchell. 2002. Candida albicans Mds3p: a conserved regulator of PH responses and virulence identified through insertional mutagenesis. Genetics 162:1573-1581

de Bruin, R. A., W. H. McDonald, T. I. Kalashnikova, J. Yates III, and C. Wittenberg. 2004. Cln3 activates G1-specific transcription via phosphorylation of the SBF bound repressor Whi5. Cell 117:887-898.

Di Como, C. J., H. Chang, and K. T. Arndt. 1995. Activation of CLN1 and CLN2 G1 cyclin gene expression by BCK2. Mol. Cell. Biol. 15:1835-1846

Feng, Q., E. Summers, B. Guo, and G. Fink. 1999. Ras signaling is required for serum-induced hyphal differentiation in Candida albicans. J. Bacteriol. 181:6339-6346.

Fonzi, W. A., and M. Y. Irwin. 1993. Isogenic strain construction and gene mapping in Candida albicans. Genetics 134:717-728

Gallego, C., E. Gari, N. Colomina, E. Herrero, and M. Aldea. 1997. The Cln3 cyclin is down-regulated by translational repression and degradation during the G1 arrest caused by nitrogen deprivation in budding yeast. EMBO J. 16:7196-7206

Gari, E., T. Volpe, H. Wang, C. Gallego, B. Futcher, and M. Aldea. 2001. Whi3 binds the mRNA of the G1 cyclin CLN3 to modulate cell fate in budding yeast. Genes Dev. 15:2803-2808

Gola S., R. Martin, A. Walther, A. Dunkler, and J. Wendland. 2003. New modules for PCR-based gene targeting in Candida albicans: rapid and efficient gene targeting using 100 bp of flanking homology region. Yeast 20:1339-1347

Hall, D. D., D. D. Markwardt, F. Parviz, and W. Heideman. 1998. Regulation of the Cln3-Cdc28 kinase by cAMP in Saccharomyces cerevisiae. EMBO J. 17:4370-4378

Hatakeyama, M., J. A. Brill, G. R. Fink, and R. A. Weinberg. 1994. Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein. Genes Dev. 8:1759-1771

Hazan, I., M. Sepulveda-Becerra, and H. Liu. 2002. Hyphal elongation is regulated independently of cell cycle in Candida albicans. Mol. Biol. Cell 13:134-145

Ho, A., and S. F. Dowdy. 2002. Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes. Curr. Opin. Genet. Dev. 12:47-52

Jeoung, D. I., L. J. Oehlen, and F. R. Cross. 1998. Cln3-associated kinase activity in Saccharomyces cerevisiae is regulated by the mating factor pathway. Mol. Cell. Biol. 18:433-441

Laabs, T. L., D. D. Markwardt, M. G. Slattery, L. L. Newcomb, D. J. Stillman, and W. Heideman. 2003. ACE2 is required for daughter cell-specific G1 delay in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 100:10275-10280

Leberer, E., D. Harcus, I. D. Broadbent, K. L. Clark, D. Dignard, K. Ziegelbauer, A. Schmidt, N. A. Gow, A. J. Brown, and D. Y. Thomas. 1996. Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans. Proc. Natl. Acad. Sci. USA 93:13217-13222

Leberer, E., D. Harcus, D. Dignard, L. Johnson, S. Ushinsky, D. Y. Thomas, and K. Schroppel. 2001. Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signalling pathways in the pathogenic fungus Candida albicans. Mol. Microbiol. 42:673-687

Lo, H. J., J. R. Kohler, B. DiDomenico, D. Loebenberg, A. Cacciapuoti, and G. R. Fink. 1997. Nonfilamentous C. albicans mutants are avirulent. Cell 90:939-949.

Loeb, J. D., T. A. Kerentseva, T. Pan, M. Sepulveda-Becerra, and H. Liu. 1999. Saccharomyces cerevisiae G1 cyclins are differentially involved in invasive and pseudohyphal growth independent of the filamentation mitogen-activated protein kinase pathway. Genetics 153:1535-1546

Loeb, J. D., M. Sepulveda-Becerra, I. Hazan, and H. Liu. 1999. A G1 cyclin is necessary for maintenance of filamentous growth in Candida albicans. Mol. Cell. Biol. 19:4019-4027

Moffat J., and B. Andrews. 2004. Late-G1 cyclin-CDK activity is essential for control of cell morphogenesis in budding yeast. Nat. Cell Biol. 6:59-66

Nantel, A., D. Dignard, C. Bachewich, D. Harcus, A. Marcil, A. P. Bouin, C. W. Sensen, H. Hogues, M. van het Hoog, P. Gordon, T. Rigby, F. Benoit, D. C. Tessier, D. Y. Thomas, and M. Whiteway. 2002. Transcription profiling of Candida albicans cells undergoing the yeast-to-hyphal transition. Mol. Biol. Cell 13:3452-3465

Nash, R., G. Tokiwa, S. Anand, K. Erickson, and A. B. Futcher. 1988. The WHI1+ gene of Saccharomyces cerevisiae tethers cell division to cell size and is a cyclin homolog. EMBO J. 7:4335-4346

Newcomb, L. L., D. D. Hall, and W. Heideman. 2002. AZF1 is a glucose-dependent positive regulator of CLN3 transcription in Saccharomyces cerevisiae. Mol. Cell. Biol. 22:1607-1614

Rupes, I. 2002. Checking cell size in yeast. Trends Genet. 18:479-485

Schneper, L., A. Krauss, R. Miyamoto, S. Fang, and J. R. Broach. 2004. The Ras/protein kinase A pathway acts in parallel with the Mob2/Cbk1 pathway to effect cell cycle progression and proper bud site selection. Eukaryot. Cell 3:108-120

Sherlock, G., A. M. Bahman, A. Mahal, J. C. Shieh, M. Ferreira, and J. Rosamond. 1994. Molecular cloning and analysis of CDC28 and cyclin homologues from the human fungal pathogen Candida albicans. Mol. Gen. Genet. 245:716-723

Sudbery, P., N. Gow, and J. Berman. 2004. The distinct morphogenic states of Candida albicans. Trends Microbiol. 12:317-324

Sudbery, P. E. 2001. The germ tubes of Candida albicans hyphae and pseudohyphae show different patterns of septin ring localization. Mol. Microbiol. 41:19-31

Wijnen, H., and B. Futcher. 1999. Genetic analysis of the shared role of CLN3 and BCK2 at the G(1)-S transition in Saccharomyces cerevisiae. Genetics 153:1131-1143

Wittenberg, C., and R. La Valle. 2003. Cell-cycle-regulatory elements and the control of cell differentiation in the budding yeast. Bioessays 25:856-867

Wolkow, T. D., S. D. Harris, and J. E. Hamer. 1996. Cytokinesis in Aspergillus nidulans is controlled by cell size, nuclear positioning and mitosis. J. Cell Sci. 109:2179-2188

Zheng, X., W. Y., Wang. 2004. Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesis. EMBO J. 23:1845-1856.
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