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The Human Gut Microbiota: Toward an Ecology of Disease


The Human Gut Microbiota: Toward an Ecology of Disease

Selber-Hnatiw, Susannah, Rukundo, Belise, et al., (105 authors) and Gamberi, Chiara (2017) The Human Gut Microbiota: Toward an Ecology of Disease. Frontiers in Microbiology, 8 (1265). pp. 1-19.

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Official URL: https://doi.org/10.3389/fmicb.2017.01265


Composed of trillions of individual microbes, the human gut microbiota has adapted to the uniquely diverse environments found in the human intestine. Quickly responding to the variances in the ingested food, the microbiota interacts with the host via reciprocal biochemical signaling to coordinate the exchange of nutrients and proper immune function. Host and microbiota function as a unit which guards its balance against invasion by potential pathogens and which undergoes natural selection. Disturbance of the microbiota composition, or dysbiosis, is often associated with human disease, indicating that, while there seems to be no unique optimal composition of the gut microbiota, a balanced community is crucial for human health. Emerging knowledge of the ecology of the microbiota-host synergy will have an impact on how we implement antibiotic treatment in therapeutics and prophylaxis and how we will consider alternative strategies of global remodeling of the microbiota such as fecal transplants. Here we examine the microbiota-human host relationship from the perspective of the microbial community dynamics.

Divisions:Concordia University > Faculty of Arts and Science > Biology
Item Type:Article
Authors:Selber-Hnatiw, Susannah and Rukundo, Belise and et al., (105 authors) and Gamberi, Chiara
Journal or Publication:Frontiers in Microbiology
Date:17 July 2017
  • Concordia Open Access Author Fund
Digital Object Identifier (DOI):10.3389/fmicb.2017.01265
Keywords:human gut microbiota, host-microbe interactions, dysbiosis, disease, gut ecology
ID Code:981944
Deposited On:11 Oct 2016 12:59
Last Modified:18 Jan 2018 17:54
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