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The aging clock: circadian rhythms and later life


The aging clock: circadian rhythms and later life

Hood, Suzanne and Amir, Shimon ORCID: https://orcid.org/0000-0003-1919-5023 (2017) The aging clock: circadian rhythms and later life. Journal of Clinical Investigation, 127 (2). pp. 437-446. ISSN 0021-9738

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Official URL: http://dx.doi.org/10.1172/JCI90328


Circadian rhythms play an influential role in nearly all aspects of physiology and behavior in the vast majority of species on Earth. The biological clockwork that regulates these rhythms is dynamic over the lifespan: rhythmic activities such as sleep/wake patterns change markedly as we age, and in many cases they become increasingly fragmented. Given that prolonged disruptions of normal rhythms are highly detrimental to health, deeper knowledge of how our biological clocks change with age may create valuable opportunities to improve health and longevity for an aging global population. In this Review, we synthesize key findings from the study of circadian rhythms in later life, identify patterns of change documented to date, and review potential physiological mechanisms that may underlie these changes.

Divisions:Concordia University > Faculty of Arts and Science > Psychology
Item Type:Article
Authors:Hood, Suzanne and Amir, Shimon
Journal or Publication:Journal of Clinical Investigation
Date:February 2017
  • Natural Sciences and Engineering Research Council of Canada
  • Les Fonds de la recherche en santé Québec
  • Canadian Institutes for Health Research
Digital Object Identifier (DOI):10.1172/JCI90328
ID Code:983744
Deposited By: Danielle Dennie
Deposited On:13 Apr 2018 15:33
Last Modified:13 Apr 2018 15:33


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