Phillips, Natalie A., Johns, Erin, Fraga, Francisco J., Mamani, Godofredo Quispe, Tavares, Guilherme and Falk, Tiago H. (2018) Early diagnosis of mild cognitive impairment and Alzheimer’s with event-related potentials and event-related desynchronization in N-back working memory tasks. Computer Methods and Programs in Biomedicine, 164 . pp. 1-13. ISSN 01692607 (In Press)
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Official URL: http://dx.doi.org/10.1016/j.cmpb.2018.06.011
Abstract
Background and Objective: In this study we investigate whether or not event-related potentials (ERP) and/or event-related (de)synchronization (ERD/ERS) can be used to differentiate between 27 healthy elderly (HE), 21 subjects diagnosed with mild cognitive impairment (MCI) and 15 mild Alzheimer’s disease (AD) patients. Methods: Using 32-channel EEG recordings, we measured ERP responses to a three-level (N-back, N = 0,1,2) visual working memory task. We also performed ERD analysis over the same EEG data, dividing the full-band signal into the well-known delta, theta, alpha, beta and gamma bands. Both ERP and ERD analyses were followed by cluster analysis with correction for multicomparisons whenever significant differences were found between groups. Results: Regarding ERP (full-band analysis), our findings have shown both patient groups (MCI and AD) with reduced P450 amplitude (compared to HE controls) in the execution of the non-match 1-back task at many scalp electrodes, chiefly at parietal and centro-parietal areas. However, no significant differences were found between MCI and AD in ERP analysis whatever was the task. As for sub-band analyses, ERD/ERS measures revealed that HE subjects elicited consistently greater alpha ERD responses than MCI and AD patients during the 1-back task in the match condition, with all differences located at frontal, central and occipital regions. Moreover, in the non-match condition, it was possible to distinguish between MCI and AD patients when they were performing the 0-back task, with MCI presenting more desynchronization than AD on the theta band at temporal and fronto-temporal areas. In summary, ERD analyses have revealed themselves more valuable than ERP, since they showed significant differences in all three group comparisons: HE vs. MCI, HE vs. AD, and MCI vs. AD. Conclusions: Based on these findings, we conclude that ERD responses to working memory (N-back) tasks could be useful not only for early MCI diagnosis or for improved AD diagnosis, but probably also for assessing the likelihood of
| Divisions: | Concordia University > Faculty of Arts and Science > Psychology |
|---|---|
| Item Type: | Article |
| Refereed: | Yes |
| Authors: | Phillips, Natalie A. and Johns, Erin and Fraga, Francisco J. and Mamani, Godofredo Quispe and Tavares, Guilherme and Falk, Tiago H. |
| Journal or Publication: | Computer Methods and Programs in Biomedicine |
| Date: | 5 July 2018 |
| Funders: |
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| Digital Object Identifier (DOI): | 10.1016/j.cmpb.2018.06.011 |
| Keywords: | Alzheimer’S disease; Mild cognitive impairment; Working memory; Event-related potentials; Event-related (de)synchronization |
| ID Code: | 984023 |
| Deposited By: | ALINE SOREL |
| Deposited On: | 06 Jul 2018 13:51 |
| Last Modified: | 27 Jun 2019 00:00 |
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