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Early diagnosis of mild cognitive impairment and Alzheimer’s with event-related potentials and event-related desynchronization in N-back working memory tasks


Early diagnosis of mild cognitive impairment and Alzheimer’s with event-related potentials and event-related desynchronization in N-back working memory tasks

Phillips, Natalie A., Johns, Erin, Fraga, Francisco J., Mamani, Godofredo Quispe, Tavares, Guilherme and Falk, Tiago H. (2018) Early diagnosis of mild cognitive impairment and Alzheimer’s with event-related potentials and event-related desynchronization in N-back working memory tasks. Computer Methods and Programs in Biomedicine, 164 . pp. 1-13. ISSN 01692607 (In Press)

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Official URL: http://dx.doi.org/10.1016/j.cmpb.2018.06.011


Background and Objective: In this study we investigate whether or not event-related potentials (ERP) and/or event-related (de)synchronization (ERD/ERS) can be used to differentiate between 27 healthy elderly (HE), 21 subjects diagnosed with mild cognitive impairment (MCI) and 15 mild Alzheimer’s disease (AD) patients. Methods: Using 32-channel EEG recordings, we measured ERP responses to a three-level (N-back, N = 0,1,2) visual working memory task. We also performed ERD analysis over the same EEG data, dividing the full-band signal into the well-known delta, theta, alpha, beta and gamma bands. Both ERP and ERD analyses were followed by cluster analysis with correction for multicomparisons whenever significant differences were found between groups. Results: Regarding ERP (full-band analysis), our findings have shown both patient groups (MCI and AD) with reduced P450 amplitude (compared to HE controls) in the execution of the non-match 1-back task at many scalp electrodes, chiefly at parietal and centro-parietal areas. However, no significant differences were found between MCI and AD in ERP analysis whatever was the task. As for sub-band analyses, ERD/ERS measures revealed that HE subjects elicited consistently greater alpha ERD responses than MCI and AD patients during the 1-back task in the match condition, with all differences located at frontal, central and occipital regions. Moreover, in the non-match condition, it was possible to distinguish between MCI and AD patients when they were performing the 0-back task, with MCI presenting more desynchronization than AD on the theta band at temporal and fronto-temporal areas. In summary, ERD analyses have revealed themselves more valuable than ERP, since they showed significant differences in all three group comparisons: HE vs. MCI, HE vs. AD, and MCI vs. AD. Conclusions: Based on these findings, we conclude that ERD responses to working memory (N-back) tasks could be useful not only for early MCI diagnosis or for improved AD diagnosis, but probably also for assessing the likelihood of

Divisions:Concordia University > Faculty of Arts and Science > Psychology
Item Type:Article
Authors:Phillips, Natalie A. and Johns, Erin and Fraga, Francisco J. and Mamani, Godofredo Quispe and Tavares, Guilherme and Falk, Tiago H.
Journal or Publication:Computer Methods and Programs in Biomedicine
Date:5 July 2018
  • São Paulo Research Foundation (FAPESP)
Digital Object Identifier (DOI):10.1016/j.cmpb.2018.06.011
Keywords:Alzheimer’S disease; Mild cognitive impairment; Working memory; Event-related potentials; Event-related (de)synchronization
ID Code:984023
Deposited By: ALINE SOREL
Deposited On:06 Jul 2018 13:51
Last Modified:27 Jun 2019 00:00


S.E. Black, S. Gauthier, W. Dalziel, R. Keren, J. Correia, H. Hew, C. BinderCanadian Alzheimer’s disease caregiver survey: baby-boomer caregivers and burden of care, Int. J. Geriatr. Psychiatry, 25 (8) (2010), pp. 807-813, 10.1002/gps.2421

R.C. Petersen, G.E. Smith, S.C. Waring, R.J. Ivnik, E.G. Tangalos, E. KokmenMild cognitive impairment: clinical characterization and outcome, Arch. Neurol., 56 (3) (1999), pp. 303-308

R.C. Petersen, J.C. Stevens, M. Ganguli, E.G. Tangalos, J.L. Cummings, S.T. DeKoskyPractice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review). report of the quality standards subcommittee of the american academy of neurology, Neurology, 56 (9) (2001), pp. 1133-1142

K. Tifratene, P. Robert, A. Metelkina, C. Pradier, J.F. DartiguesProgression of mild cognitive impairment to dementia due to ad in clinical settings, Neurology, 85 (4) (2015), pp. 331-338, 10.1212/WNL.0000000000001788

K. Budolfson, M. Malek-Ahmadi, C.M. Belden, J. Powell, K. Davis, S. Jacobson, M.N. SabbaghNeuropsychological correlates of the Alzheimer’s questionnaire, J. Alzheimers Dis. (2015), 10.3233/jad-142388

W. Thies, L. BleilerAlzheimer’S association, 2013 alzheimer’s disease facts and figures, Alzheimers Dement, 9 (2) (2013), pp. 208-245, 10.1016/j.jalz.2013.02.003

C. Babiloni, C.D. Percio, R. Lizio, G. Noce, S. Lopez, A. Soricelli, R. Ferri, F. Nobili, D. Arnaldi, F. Famà, D. Aarsland, F. Orzi, C. Buttinelli, F. Giubilei, M. Onofrj, F. Stocchi, P. Stirpe, P. Fuhr, U. Gschwandtner, G. Ransmayr, H. Garn, L. Fraioli, M. Pievani, G.B. Frisoni, F. D’Antonio, C.D. Lena, B. Güntekin, L. Hanoğlu, E. Başar, G. Yener, D.D. Emek-Savaş, A.I. Triggiani, R. Franciotti, J.P. Taylor, L. Vacca, M.F.D. Pandis, L. BonanniAbnormalities of resting state functional cortical connectivity in patients with dementia due to Alzheimer’s and lewy body diseases: an EEG study, Neurobiol. Aging (2017), 10.1016/j.neurobiolaging.2017.12.023

S. Hulbert, H. AdeliEeg/meg- and imaging-based diagnosis of alzheimer’s disease, Rev. Neurosci., 24 (6) (2013), pp. 563-576, 10.1515/revneuro-2013-0042

J. Dauwels, F. Vialatte, A. CichockiDiagnosis of alzheimer’s disease from eeg signals: where are we standing?, Curr. Alzheimer Res., 7 (6) (2010), pp. 487-505

J. JeongEeg dynamics in patients with alzheimer’s disease, Clin. Neurophysiol., 115 (7) (2004), pp. 1490-1505, 10.1016/j.clinph.2004.01.001

E.C. van Straaten, P. Scheltens, A.A. Gouw, C.J. StamEyes-closed task-free electroencephalography in clinical trials for alzheimer’s disease: an emerging method based upon brain dynamics, Alzheimers Res. Ther., 6 (9) (2014), p. 86, 10.1186/s13195-014-0086-x

P.A.M. Kanda, L.R. Trambaiolli, A.C. Lorena, F.J. Fraga, L.F.I. Basile, R. Nitrini, R. AnghinahClinician’S road map to wavelet EEG as an Alzheimer’s disease biomarker, Clin. EEG Neurosci., 45 (2) (2014), pp. 104-112, 10.1177/1550059413486272

F.J. Fraga, T.H. Falk, L.R. Trambaiolli, E.F. Oliveira, W.H.L. Pinaya, P.A.M. Kanda, R. AnghinahTowards an EEG-based biomarker for Alzheimer’s disease: Improving amplitude modulation analysis features, Proceedings of the IEEE International Conference on Acoustics, Speech and Signal Processing (2013), pp. 1207-1211, 10.1109/ICASSP.2013.6637842

R. Cassani, T.H. Falk, F.J. Fraga, P.A. Kanda, R. AnghinahTowards automated EEG-Based Alzheimer’s disease diagnosis using relevance vector machines ,Proceedings of the 5th ISSNIP-IEEE Biosignals and Biorobotics Conference: Biosignals and Robotics for Better and Safer Living (BRC) (2014), pp. 1-6, 10.1109/BRC.2014.6880978

P.A.M. Kanda, E.F. Oliveira, F.J. FragaEEG Epochs with less alpha rhythm improve discrimination of mild Alzheimer’s, Comput. Methods Programs Biomed., 138 (2017), pp. 13-22, 10.1016/j.cmpb.2016.09.023

M.M.A. Engels, W.M. van der Flier, C.J. Stam, A. Hillebrand, P. Scheltens, E.C.W. van StraatenAlzheimer’S disease: the state of the art in resting-state magnetoencephalography, Clin. Neurophysiol, 128 (8) (2017), pp. 1426-1437, 10.1016/j.clinph.2017.05.012

C. Morrison, S. Rabipour, F. Knoefel, C. ShepardAuditory event-related potentials in mild cognitive impairment and alzheimer’s disease: a literature review, Curr. Alzheimer Res. (2018), 10.2174/1567205015666180123123209
R.V. Pedroso, F.J. Fraga, D.I. Corazza, C.A.A. Andreatto, F.G.d.M. Coelho, J.R. Costa, R.F. Santos-GaldurózP300 Latency and amplitude in Alzheimer’s disease: a systematic review, Braz. J. Otorhinolaryngol., 78 (2012), pp. 126-132

G.Q. Mamani, F.J. Fraga, G. Tavares, E. Johns, N.D. PhillipsEEG-based biomarkers on working memory tasks for early diagnosis of Alzheimer’s disease and mild cognitive impairment, Proceedings of the IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT) (2017), pp. 237-240, 10.1109/HIC.2017.8227628

F.J. Fraga, L.A. Ferreira, T.H. Falk, E. Johns, N.D. PhillipsEvent-related synchronisation responses to n-back memory tasks discriminate between healthy ageing, mild cognitive impairment, and mild Alzheimer’s disease, Proceedings of the IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP) (2017), pp. 964-968, 10.1109/ICASSP.2017.7952299

R.V. Pedroso, F.J. Fraga, C. Ayán, J. Cancela Carral, L. Scarpari, R.F. Santos-GaldurózEffects of physical activity on the P300 component in elderly people: a systematic review, Psychogeriatrics (2017), 10.1111/psyg.12242

R. Ishii, L. Canuet, Y. Aoki, M. Hata, M. Iwase, S. Ikeda, K. Nishida, M. IkedaHealthy and pathological brain aging: from the perspective of oscillations, functional connectivity, and signal complexity, Neuropsychobiology, 75 (4) (2017), pp. 151-161, 10.1159/000486870

M.J. Kas, B. Penninx, B. Sommer, A. Serretti, C. Arango, H. MarstonA quantitative approach to neuropsychiatry: the why and the how, Neurosci. Biobehav. Rev. (2017), 10.1016/j.neubiorev.2017.12.008

C. Laske, H.R. Sohrabi, S.M. Frost, K. López-de Ipiña, P. Garrard, M. Buscema, J. Dauwels, S.R. Soekadar, S. Mueller, C. Linnemann, S.A. Bridenbaugh, Y. Kanagasingam, R.N. Martins, S.E. O’BryantInnovative diagnostic tools for early detection of alzheimer’s disease, Alzheimers Dement, 11 (5) (2015), pp. 561-578, 10.1016/j.jalz.2014.06.004

M.A. Hird, P. Egeto, C.E. Fischer, G. Naglie, T.A. SchweizerA systematic review and meta-analysis of on-road simulator and cognitive driving assessment in Alzheimer’s disease and mild cognitive impairment, J. Alzheimers Dis. (2016), 10.3233/JAD-160276

E.K. Johns, N.A. Phillips, S. Belleville, D. Goupil, L. Babins, N. Kelner, B. Ska, B. Gilbert, F. Massoud, C. de Boysson, H.D. Duncan, H. ChertkowThe profile of executive functioning in amnestic mild cognitive impairment: disproportionate deficits in inhibitory control, J. Int. Neuropsychol. Soc., 18 (3) (2012), pp. 541-555, 10.1017/S1355617712000069

D.P. Salmon, M.W. BondiNeuropsychological assessment of dementia,Annu. Rev. Psychol., 60 (2009), pp. 257-282, 10.1146/annurev.psych.57.102904.190024

A.L.W. Bokde, M. Ewers, H. HampelAssessing neuronal networks: understanding Alzheimer’s disease, Prog. Neurobiol., 89 (2) (2009), pp. 125-133, 10.1016/j.pneurobio.2009.06.004

R. Duara, D.A. Loewenstein, M.T. Greig, E. Potter, W. Barker, A. Raj, J. Schinka, A. Borenstein, M. Schoenberg, Y. Wu, J. Banko, H. PotterPre-MCI and MCI: neuropsychological, clinical, and imaging features and progression rates, Am. J. Geriatr. Psychiatry, 19 (11) (2011), pp. 951-960, 10.1097/JGP.0b013e3182107c69

R.M. Chapman, J.W. McCrary, M.N. Gardner, T.C. Sandoval, M.D. Guillily, L.A. Reilly, E. DeGrushBrain ERP components predict which individuals progress to Alzheimer’s disease and which do not, Neurobiol. Aging, 32 (2011), pp. 1742-1755, 10.1016/j.neurobiolaging.2009.11.010

P. Missonnier, M.P. Deiber, G. Gold, F.R. Herrmann, P. Millet, A. Michon, L. Fazio-Costa, V. Ibanez, P. GiannakopoulosWorking memory load-related electroencephalographic parameters can differentiate progressive from stable mild cognitive impairment, Neuroscience, 150 (2007), pp. 346-356, 10.1016/j.neuroscience.2007.09.009

P. Missonnier, G. Gold, L. Fazio-Costa, J.-P. Michel, R. Mulligan, A. Michon, V. Ibáñez, P. GiannakopoulosEarly event-related potential changes during working memory activation predict rapid decline in mild cognitive impairment, J. Gerontol. A Biol. Sci. Med. Sci., 60 (5) (2005), pp. 660-666

D.V. Moretti, C. Babiloni, G. Binetti, E. Cassetta, G. Dal Forno, F. Ferreric, R. Ferri, B. Lanuzza, C. Miniussi, F. Nobili, et al.Individual analysis of EEG frequency and band power in mild Alzheimer’s disease, Clin. Neurophysiol., 115 (2) (2004), pp. 299-308

L.R. Trambaiolli, A.C. Lorena, F.J. Fraga, P.A.M. Kanda, R. Anghinah, R. NitriniImproving Alzheimer’s disease diagnosis with machine learning techniques, Clin. EEG Neurosci., 42 (3) (2011), pp. 160-165

R. Cassani, T.H. Falk, F.J. Fraga, P.A.M. Kanda, R. AnghinahThe effects of automated artifact removal algorithms on electroencephalography-based Alzheimer’s disease diagnosis, Front. Aging Neurosci., 6 (2014), p. 55, 10.3389/fnagi.2014.00055

T.H. Falk, F.J. Fraga, L. Trambaiolli, R. AnghinahEEG Amplitude modulation analysis for semi-automated diagnosis of Alzheimer’s disease, EURASIP J. Adv. Signal Process., 2012 (1) (2012), p. 192, 10.1186/1687-6180-2012-192

F.J. Fraga, T.H. Falk, P.A.M. Kanda, R. AnghinahCharacterizing Alzheimer’s disease severity via resting-awake EEG amplitude modulation analysis, PLoS ONE, 8 (8) (2013) e72240. doi:10.1371/journal.pone.0072240

M. Karrasch, M. Laine, J. Rinne, P. Rapinoja, E. Sinerva, C. KrauseBrain oscillatory responses to an auditory-verbal working memory task in mild cognitive impairment and Alzheimer’s disease, Int. J. Psychophysiol., 59 (2006), pp. 168-178, 10.1016/j.ijpsycho.2005.04.006

G. Pfurtscheller, F. da SilvaEvent-related EEG/MEG synchronization and desynchronization: basic principles, Clin. Neurophysiol., 110 (1999), pp. 1842-1857

P.C.M. Vijn, B.W. van Dijk, H. SpekreijseVisual stimulation reduces EEG activity in man, Brain Res., 550 (1) (1991), pp. 49-53, 10.1016/0006-8993(91)90403-I

C. Başar-Eroglu, D. Strüber, M. Schürmann, M. Stadler, E. BaşarGamma-band responses in the brain: a short review of psychophysiological correlates and functional significance, Int. J. Psychophysiol., 24 (1–2) (1996), pp. 101-112, 10.1016/S0167-8760(96)00051-7

C.S. Herrmann, M.H.J. Munk, A.K. EngelCognitive functions of gamma-band activity: memory match and utilization, Trends Cogn. Sci., 8 (8) (2004), pp. 347-355, 10.1016/j.tics.2004.06.006

M. D’Esposito, G.K. Aguirre, E. Zarahn, D. Ballard, R.K. Shin, J. LeaseFunctional mri studies of spatial and nonspatial working memory, Brain Res. Cogn. Brain Res., 7 (1) (1998), pp. 1-13
A. BaddeleyWorking memory: looking back and looking forward, Nat. Rev. Neurosci., 4 (10) (2003), pp. 829-839, 10.1038/nrn1201

F. Collette, M. Hogge, E. Salmon, M. Van der LindenExploration of the neural substrates of executive functioning by functional neuroimaging, Neuroscience, 139 (1) (2006), pp. 209-221, 10.1016/j.neuroscience.2005.05.035

T. Braver, J. Cohen, L. Nystrom, J. Jonides, E. Smith, D. NollA parametric study of prefrontal cortex involvement in human working memory, Neuroimage, 5 (1997), pp. 49-62

E. Başar, C. Başar-Eroğlu, B. Güntekin, G.G. YenerBrain’S alpha, beta, gamma, delta, and theta oscillations in neuropsychiatric diseases: proposal for biomarker strategies, Suppl. Clin. Neurophysiol., 62 (2013), pp. 19-54

G. Caravaglios, E. Costanzo, F. Palermo, E.G. MuscosoDecreased amplitude of auditory event-related delta responses in Alzheimer's disease, Int. J. Psychophysiol., 70 (1) (2008), pp. 23-32, 10.1016/j.ijpsycho.2008.04.004

G.G. Yener, B. Güntekin, D.N. Örken, E. Tülay, H. Forta, E. BaşarAuditory delta event-related oscillatory responses are decreased in Alzheimer’s disease, Behav. Neurol. (2012), 10.3233/BEN-2012-0344

P. Kurt, D.D. Emek-Savaş, K. Batum, B. Turp, B. Güntekin, S. Karşdağ, G.G. YenerPatients with mild cognitive impairment display reduced auditory event-related delta oscillatory responses, Behav. Neurol., 2014 (2014), p. 268967, 10.1155/2014/268967

G.G. Yener, P. Kurt, D.D. Emek-Savaş, B. Güntekin, E. BaşarReduced visual event-related delta oscillatory responses in amnestic mild cognitive impairment, J. Alzheimers Dis., 37 (4) (2013), pp. 759-767, 10.3233/JAD-130569

G. Yener, B. Güntekin, A. Öniz, E. BaşarIncreased frontal phase-locking of event-related theta oscillations in alzheimer patients treated with cholinesterase inhibitors, Int. J. Psychophysiol., 64 (1) (2007), pp. 46-52, 10.1016/J.IJPSYCHO.2006.07.006

M.-P. Deiber, V. Ibañez, P. Missonnier, F. Herrmann, L. Fazio-Costa, G. Gold, P. GiannakopoulosAbnormal-induced theta activity supports early directed-attention network deficits in progressive MCI, Neurobiol. Aging, 30 (2009), pp. 1444-1452, 10.1016/j.neurobiolaging.2007.11.021

T.D. Cummins, M. Broughton, S. FinniganTheta oscillations are affected by amnestic mild cognitive impairment and cognitive load, Int. J. Psychophysiol., 70 (1) (2008), pp. 75-81, 10.1016/J.IJPSYCHO.2008.06.002

C. Babiloni, E. Cassetta, P. Chiovenda, C. Del Percio, M. Ercolani, D.V. Moretti, F. Moffa, P. Pasqualetti, V. Pizzella, G.L. Romani, F. Tecchio, F. Zappasodi, P.M. RossiniAlpha rhythms in mild dements during visual delayed choice reaction time tasks: a MEG study, Brain Res. Bull., 65 (6) (2005), pp. 457-470, 10.1016/J.BRAINRESBULL.2005.01.014

M.P. Deiber, H.B. Meziane, R. Hasler, C. Rodriguez, S. Toma, M. Ackermann, F. Herrmann, P. GiannakopoulosAttention and working memory-Related EEG markers of subtle cognitive deterioration in healthy elderly individuals, J. Alzheimers Dis., 47 (2) (2015), pp. 335-349, 10.3233/JAD-150111

R. Kurimoto, R. Ishii, L. Canuet, K. Ikezawa, M. Iwase, M. Azechi, Y. Aoki, S. Ikeda, T. Yoshida, H. Takahashi, T. Nakahachi, H. Kazui, M. TakedaInduced oscillatory responses during the Sternberg’s visual memory task in patients with Alzheimer’s disease and mild cognitive impairment, Neuroimage, 59 (4) (2012), pp. 4132-4140, 10.1016/J.NEUROIMAGE.2011.10.061

B. Güntekin, D.D. Emek-Savaş, P. Kurt, G.G. Yener, E. BaşarBeta oscillatory responses in healthy subjects and subjects with mild cognitive impairment, NeuroImage: Clin., 3 (2013), pp. 39-46, 10.1016/j.nicl.2013.07.003

E. Başar, D.D. Emek-Savaş, B. Güntekin, G.G. YenerDelay of cognitive gamma responses in Alzheimer’s disease, NeuroImage Clin., 11 (2016), pp. 106-115, 10.1016/J.NICL.2016.01.015

A. Mouraux, G.D. IannettiAcross-trial averaging of event-related EEG responses and beyond, Magn. Reson. Imaging, 26 (7) (2008), pp. 1041-1054, 10.1016/j.mri.2008.01.011

L. Leocani, G. ComiMovement-related event-related desynchronization in neuropsychiatric disorders, Prog. Brain Res., 159 (2006), pp. 351-366, 10.1016/S0079-6123(06)59023-5
G. Pfurtscheller, C. AndrewEvent-related changes of band power and coherence: methodology and interpretation, J. Clin. Neurophysiol., 16 (6) (1999), pp. 512-519

J.A. Yesavage, T.L. Brink, T.L. Rose, O. Lum, V. Huang, M. Adey, V.O. LeirerDevelopment and validation of a geriatric depression screening scale: a preliminary report, J. Psychiatry Res., 17 (1) (1982), pp. 37-49

Z.S. Nasreddine, N.A. Phillips, V. Bédirian, S. Charbonneau, V. Whitehead, I. Collin, J.L. Cummings, H. ChertkowThe montreal cognitive assessment, moca: a brief screening tool for mild cognitive impairment, J. Am. Geriatr. Soc., 53 (4) (2005), pp. 695-699, 10.1111/j.1532-5415.2005.53221.x

B. Winblad, K. Palmer, M. Kivipelto, V. Jelic, L. Fratiglioni, L.-O. Wahlund, A. Nordberg, L. Bäckman, M. Albert, O. Almkvist, H. Arai, H. Basun, K. Blennow, M. de Leon, C. DeCarli, T. Erkinjuntti, E. Giacobini, C. Graff, J. Hardy, C. Jack, A. Jorm, K. Ritchie, C. van Duijn, P. Visser, R.C. PetersenMild cognitive impairment–beyond controversies, towards a consensus: report of the international working group on mild cognitive impairment, J. Intern. Med., 256 (3) (2004), pp. 240-246, 10.1111/j.1365-2796.2004.01380.x

R.C. Petersen, R.O. Roberts, D.S. Knopman, B.F. Boeve, Y.E. Geda, R.J. Ivnik, G.E. Smith, C.R. Jack JrMild cognitive impairment: ten years later, Arch. Neurol., 66 (12) (2009), pp. 1447-1455, 10.1001/archneurol.2009.266

G. McKhann, D. Drachman, M. Folstein, R. Katzman, D. Price, E.M. StadlanClinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer’s disease, Neurology, 34 (7) (1984), pp. 939-944

A. Delorme, S. MakeigEEGLAB: An open source toolbox for analysis of single-trial EEG dynamics including independent component analysis, J. Neurosci. Methods, 134 (1) (2004), pp. 9-21, 10.1016/j.jneumeth.2003.10.009

G. PfurtschellerEvent-related synchronization (ERS) - an electrophysiological correlate of cortical areas at rest, Electroencephalogr. Clin. Neurophysiol., 83 (1992), pp. 62-69

S. Sanei, J. ChambersEEG Signal processing, Wiley-Interscience (2007)

G. Pfurtscheller, B. Graimann, J.E. Huggins, S.P. Levine, L.A. SchuhSpatiotemporal patterns of beta desynchronization and gamma synchronization in corticographic data during self-paced movement, Clin. Neurophysiol., 114 (7) (2003), pp. 1226-1236

B. EverittCluster Analysis (fifth ed.), Wiley series in probability and statistics, Wiley, Chichester, West Sussex, U.K. (2011)

E. Maris, R. OostenveldNonparametric statistical testing of EEG- and MEG-data, J. Neurosci. Methods, 164 (1) (2007), pp. 177-190, 10.1016/j.jneumeth.2007.03.024

Y. Xu, G.P. Sudre, W. Wang, D.J. Weber, R.E. KassCharacterizing global statistical significance of spatiotemporal hot spots in magnetoencephalography/ electroencephalography source space via excursion algorithms, Stat. Med., 30 (23) (2011), pp. 2854-2866, 10.1002/sim.4309

D.M. Groppe, T.P. Urbach, M. KutasMass univariate analysis of event-related brain potentials/fields ii: simulation studies, Psychophysiology, 48 (12) (2011), pp. 1726-1737, 10.1111/j.1469-8986.2011.01272.x

D.M. Groppe, T.P. Urbach, M. KutasMass univariate analysis of event-related brain potentials/fields i: a critical tutorial review, Psychophysiology, 48 (12) (2011), pp. 1711-1725, 10.1111/j.1469-8986.2011.01273.x

J.A. Urigüen, B. García-Zapirain, J. Artieda, J. Iriarte, M. ValenciaComparison of background eeg activity of different groups of patients with idiopathic epilepsy using shannon spectral entropy and cluster-based permutation statistical testing, PLoS ONE, 12 (9) (2017), p. e0184044, 10.1371/journal.pone.0184044

N.J. Williams, S.J. Nasuto, J.D. SaddyMethod for exploratory cluster analysis and visualisation of single-trial erp ensembles, J. Neurosci. Methods, 250 (2015), pp. 22-33, 10.1016/j.jneumeth.2015.02.007

T. Kanungo, D.M. Mount, N.S. Netanyahu, C.D. Piatko, R. Silverman, A.Y. WuAn efficient k-means clustering algorithm: analysis and implementation,IEEE Trans. Pattern Anal. Mach. Intell., 24 (7) (2002), pp. 881-892, 10.1109/TPAMI.2002.1017616
R. Oostenveld, P. Fries, E. Maris, J.-M. SchoffelenFieldtrip: open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data, Comput. Intell. Neurosci., 2011 (2011), p. 9, 10.1155/2011/156869

S. Weintraub, L. Besser, H.H. Dodge, M. Teylan, S. Ferris, F.C. Goldstein, B. Giordani, J. Kramer, D. Loewenstein, D. Marson, D. Mungas, D. Salmon, K. Welsh-Bohmer, X.-H. Zhou, S.D. Shirk, A. Atri, W.A. Kukull, C. Phelps, J.C. MorrisVersion 3 of the alzheimer disease centers’ neuropsychological test battery in the uniform data set (UDS), Alzheimer Dis. Assoc. Disord. (2017), 10.1097/wad.0000000000000223

R.A. López Zunini, F. Knoefel, C. Lord, F. Dzuali, M. Breau, L. Sweet, R. Goubran, V. TalerEvent-related potentials elicited during working memory are altered in mild cognitive impairment, Int. J. Psychophysiol., 109 (2016), pp. 1-8, 10.1016/j.ijpsycho.2016.09.012

P. Missonnier, G. Gold, F.R. Herrmann, L. Fazio-Costa, J.-P. Michel, M.-P. Deiber, A. Michon, P. GiannakopoulosDecreased theta event-related synchronization during working memory activation is associated with progressive mild cognitive impairment, Dement Geriatr. Cogn. Disord., 22 (3) (2006), pp. 250-259, 10.1159/000094974

M.-P. Deiber, V. Ibañez, P. Missonnier, F. Herrmann, L. Fazio-Costa, G. Gold, P. GiannakopoulosAbnormal-induced theta activity supports early directed-attention network deficits in progressive MCI, Neurobiol. Aging, 30 (9) (2009), pp. 1444-1452, 10.1016/j.neurobiolaging.2007.11.021

S.E. Bruce, K.B. Werner, B.F. Preston, L.M. BakerImprovements in concentration, working memory and sustained attention following consumption of a natural citicoline-caffeine beverage, Int. J. Food Sci. Nutr., 65 (8) (2014), pp. 1003-1007, 10.3109/09637486.2014.940286

H.A.D. Keage, C.R. Clark, D.F. Hermens, L.M. Williams, M.R. Kohn, S. Clarke, C. Lamb, D. Crewther, E. GordonERP Indices of working memory updating in ad/hd: differential aspects of development, subtype, and medication, J. Clin. Neurophysiol., 25 (1) (2008), pp. 32-41, 10.1097/WNP.0b013e318163ccc0

G. Caravaglios, E.G. Muscoso, G. Di Maria, E. CostanzoTheta responses are abnormal in mild cognitive impairment: evidence from analysis of theta event-related synchronization during a temporal expectancy task, J. Neural Transm., 120 (7) (2013), pp. 1093-1107, 10.1007/s00702-012-0921-9

G. Pfurtscheller, W. KlimeschFunctional topography during a visuoverbal judgment task studied with event-related desynchronization mapping, J. Clin. Neurophysiol., 9 (1) (1992), pp. 120-131

W. Klimesch, H. Schimke, G. PfurtschellerAlpha frequency, cognitive load and memory performance, Brain Topogr., 5 (3) (1993), pp. 241-251

W. Klimesch, H. Schimke, J. SchwaigerEpisodic and semantic memory: an analysis in the EEG theta and alpha band, Electroencephalogr. Clin. Neurophysiol., 91 (6) (1994), pp. 428-441

M. Sterman, D. Kaiser, B. VeigelSpectral analysis of event-related EEG responses during short-term memory performance, Brain Topogr., 9 (1) (1996), pp. 21-30, 10.1007/BF01191639

C.M. Krause, L. Sillanmäki, M. Koivisto, C. Saarela, A. Häggqvist, M. Laine, H. HämäläinenThe effects of memory load on event-related EEG desynchronization and synchronization, Clin. Neurophysiol., 111 (11) (2000), pp. 2071-2078

F. Boiten, J. Sergeant, R. GeuzeEvent-related desynchronization: the effects of energetic and computational demands, Electroencephalogr. Clin. Neurophysiol., 82 (4) (1992), pp. 302-309

K. Dujardin, P. Derambure, L. Defebvre, J.L. Bourriez, J.M. Jacquesson, J.D. GuieuEvaluation of event-related desynchronization (ERD) during a recognition task: effect of attention, Electroencephalogr. Clin. Neurophysiol., 86 (5) (1993), pp. 353-356

S. SternbergHigh-speed scanning in human memory, Science, 153 (3736) (1966), pp. 652-654
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