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From Pavlov’s Dog to Rats Using Drugs


From Pavlov’s Dog to Rats Using Drugs

Khoo, Shaun Yon-Seng ORCID: https://orcid.org/0000-0002-0972-3788 (2019) From Pavlov’s Dog to Rats Using Drugs. Frontiers for Young Minds, 7 (58). ISSN 2296-6846

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Official URL: https://doi.org/10.3389/frym.2019.00058


Pavlov’s dogs became famous in 1927 for learning that the sound of a bell meant that food was coming. Today, scientists are still interested in understanding how sights, smells, sounds, and places can come to influence our behavior. These things are called cues and contexts. In drug addiction, people experience cues and contexts and drugs around the same time and formmental links or associations between the cues/contexts and the drugs. These mental links can motivate people to seek out drugs even if they are trying to quit. By studying the brain as these mental links are being formed or broken, researchers are learning about one of the things that keeps people frombreaking their addictions, and they are improving the therapies available to help people who are addicted to drugs.

Divisions:Concordia University > Research Units > Centre for Studies in Behavioural Neurobiology
Item Type:Article
Authors:Khoo, Shaun Yon-Seng
Journal or Publication:Frontiers for Young Minds
Date:11 April 2019
Digital Object Identifier (DOI):10.3389/frym.2019.00058
Keywords:classical conditioning, Pavlov, addiction, psychology, extinction, reinstatement, cues, contexts
ID Code:985262
Deposited On:24 Apr 2019 19:35
Last Modified:24 Apr 2019 19:35
Additional Information:Frontiers for Young Minds articles are written by scientists to explain concepts and new research findings to kids and the general public. The articles are reviewed by kids before publication.


[1] ↑ Pavlov, I. 1927. Conditional Reflexes: An Investigation of the Physiological Activity of the Cerebral Cortex. New York, NY: Dover Publications.

[2] ↑ Jasinska, A. J., Stein, E. A., Kaiser, J., Naumer, M. J., and Yalachkov, Y. 2014. Factors modulating neural reactivity to drug cues in addiction: a survey of human neuroimaging studies. Neurosci. Biobehav. Rev. 38:1–16. doi: 10.1016/j.neubiorev.2013.10.013

[3] ↑ Sciascia, J. M., Reese, R. M., Janak, P. H., and Chaudhri, N. 2015. Alcohol-seeking triggered by discrete pavlovian cues is invigorated by alcohol contexts and mediated by glutamate signaling in the basolateral amygdala. Neuropsychopharmacology. 40:2801–12. doi: 10.1038/npp.2015.130

[4] ↑ Bouton, M. E., and Swartzentruber, D. 1991. Sources of relapse after extinction in Pavlovian and instrumental learning. Clin. Psychol. Rev. 11:123–40. doi: 10.1016/0272-7358(91)90091-8

[5] ↑ Lawrence, A. J., Cowen, M. S., Yang, H.-J., Chen, F., and Oldfield, B. 2006. The orexin system regulates alcohol-seeking in rats. Br. J. Pharmacol. 148:752–9. doi: 10.1038/sj.bjp.0706789

[6] ↑ Campbell, E. J., Marchant, N. J., and Lawrence, A. J. 2018. A sleeping giant: suvorexant for the treatment of alcohol use disorder? Brain Res. doi: 10.1016/j.brainres.2018.08.005
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