Desharnais, Brigitte 
ORCID: https://orcid.org/0000-0001-7373-656X, Dazé, Yann, Huppertz, Laura M., Mireault, Pascal and Skinner, Cameron D.
(2017)
A case of fatal idiosyncratic reaction to the designer drug 3,4-methylenedioxypyrovalerone (MDPV) and review of the literature.
Forensic Science, Medicine and Pathology, 13
.
pp. 350-354.
ISSN 1547-769X
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Text (Post-print: final draft post-refeering) (application/pdf)
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Official URL: https://doi.org/10.1007/s12024-017-9894-1
Abstract
The stimulant designer drug 3,4-methylenedioxypyrovalerone (MDPV) was first synthesized by Boehringer Ingelheim in 1969 and introduced on the black market in 2006. Only a small number of fatal intoxication cases have been reported in the literature, all with significant blood MDPV concentrations. In this report, we describe one fatality attributed to an idiosyncratic reaction to MDPV. The victim displayed agitation, violent behavior and delirium followed by cardiac arrest. Hyperthermia was observed at the hospital. The MDPV cardiac and femoral blood concentrations were 6 ng/mL. The presence of excited delirium syndrome and MDPV, a drug with a pharmacology similar to cocaine, leads to the conclusion that the victim suffered a fatal adverse reaction to MDPV. This is the first published case of idiosyncratic reaction to MDPV.
| Divisions: | Concordia University > Faculty of Arts and Science > Chemistry and Biochemistry |
|---|---|
| Item Type: | Article |
| Refereed: | Yes |
| Authors: | Desharnais, Brigitte and Dazé, Yann and Huppertz, Laura M. and Mireault, Pascal and Skinner, Cameron D. |
| Journal or Publication: | Forensic Science, Medicine and Pathology |
| Date: | 1 July 2017 |
| Projects: |
|
| Digital Object Identifier (DOI): | 10.1007/s12024-017-9894-1 |
| Keywords: | MDPV, “bath salts”, Idiosyncratic reaction, Toxicology, Excited delirium, Adverse drug reaction |
| ID Code: | 986236 |
| Deposited By: | BRIGITTE DESHARNAIS |
| Deposited On: | 15 Jan 2020 20:45 |
| Last Modified: | 15 Jan 2020 20:50 |
| Related URLs: | |
| Additional Information: | This is a post-peer-review, pre-copyedit version of an article published in Forensic Science, Medicine and Pathology. The final authenticated version is available online at: https://doi.org/10.1007/s12024-017-9894-1 |
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