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Effects of Ovarian Hormone Replacement on the Ovariectomized (OVX) Female Rat Response to Ketamine

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Effects of Ovarian Hormone Replacement on the Ovariectomized (OVX) Female Rat Response to Ketamine

Gagne, Collin (2020) Effects of Ovarian Hormone Replacement on the Ovariectomized (OVX) Female Rat Response to Ketamine. Masters thesis, Concordia University.

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Abstract

Ketamine has been shown to acutely and rapidly ameliorate depressive symptoms and suicidality. Given that women suffer from depression at two-times the rate of men, the current work first reviews the literature at the intersection between two subjects: the neurobiological mechanisms of ketamine’s antidepressant effects, and how ovarian hormones might
interact with these phenomena. The neuroinflammatory hypothesis of depression is emphasized. Next, we investigated how the ovarian hormones 17β-estradiol and progesterone interact with ketamine’s effects on ovariectomized female Wistar rat behavior in the forced swim test. A secondary experiment analyzed the effects of ketamine on males, also in the forced swim test. No significant interaction or main
effects were found among the females, whereas ketamine significantly reduced immobility among the males. Locomotor activity recordings confirmed that ketamine’s effects in the forced swim test were not due to overall locomotor suppression.

Divisions:Concordia University > Faculty of Arts and Science > Psychology
Item Type:Thesis (Masters)
Authors:Gagne, Collin
Institution:Concordia University
Degree Name:M.A.
Program:Psychology
Date:April 2020
Thesis Supervisor(s):Brake, Wayne
ID Code:986562
Deposited By: COLLIN GAGNE
Deposited On:27 Oct 2022 13:50
Last Modified:27 Oct 2022 13:50
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