Rehan, Sana (2020) Investigating Visual Function and Cortical Structure in Groups with (or at Risk for) Alzheimer’s Dementia. Masters thesis, Concordia University.
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Abstract
Poor sensory performance is cross-sectionally associated with poorer cognition and increases risk for cognitive decline and Alzheimer’s dementia (AD). The purpose of this study was to characterize the degree of visual impairment in individuals with (or at risk for) dementia and explore the effects of this sensory-cognitive relationship on brain structure.
Using the Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) dataset, we analyzed vision and imaging data from three diagnostic groups: individuals with subjective cognitive decline (SCD; N = 53), mild cognitive impairment (MCI; N = 102), and mild AD (N = 45). We characterized used ANCOVAs to determine whether visual performance on reading acuity and contrast sensitivity differed as a function of clinical diagnosis. Cortical thickness and volume were extracted using FreeSurfer, and hierarchical regression analyses were done to determine whether visual performance predicted brain structure (i.e., cortical thickness and volume) beyond diagnostic group membership.
We found that the AD group performed significantly worse on reading acuity and contrast sensitivity compared to the SCD and MCI groups, which did not differ from each other. Despite our independent findings that visual performance differs across diagnostic groups and that group membership predicted cortical structure, our results demonstrate that visual performance does not predict cortical structure above and beyond clinical diagnosis. Our findings support the hypothesis that atrophy in underlying visual areas and pathways is responsible for the functional vision deficits observed in AD.
Divisions: | Concordia University > Faculty of Arts and Science > Psychology |
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Item Type: | Thesis (Masters) |
Authors: | Rehan, Sana |
Institution: | Concordia University |
Degree Name: | M.A. |
Program: | Psychology |
Date: | 30 July 2020 |
Thesis Supervisor(s): | Phillips, Natalie |
Keywords: | visual impairment, sensory loss, cognitive decline, cortical atrophy, cortical structure, dementia |
ID Code: | 987284 |
Deposited By: | Sana Rehan |
Deposited On: | 25 Nov 2020 15:47 |
Last Modified: | 25 Nov 2020 15:47 |
References:
Ad-Dab’bagh, Y., Lyttelton, O., Muehlboeck, J. S., Lepage, C., Einarson, D., Mok, K., Ivanov, O., Vincent, R. D., Lerch, J., & Fombonne, E. (2006). The CIVET image-processing environment: a fully automated comprehensive pipeline for anatomical neuroimaging research, in: Proceedings of the 12th Annual Meeting of the Organization for Human Brain Mapping. Florence, Italy.Albers, M., Gilmore, G., Kaye, J., Murphy, C., Wingfield, A., Bennett, D., ... Zhang, L. (2015). At the interface of sensory and motor dysfunctions and Alzheimer’s Disease. Alzheimer’s & Dementia, 11, 70–98.
Albert, M. S., DeKosky, S. T., Dickson, D., Dubois, B., Feldman, H. H., Fox, N. C., ... & Snyder, P. J. (2011). The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & Dementia, 7, 270-279.
Aljied, R., Aubin, M. J., Buhrmann, R., Sabeti, S., & Freeman, E. E. (2018). Prevalence and determinants of visual impairment in Canada: cross-sectional data from the Canadian longitudinal study on aging. Canadian Journal of Ophthalmology, 53(3), 291-297.
Alzheimer Society of Canada (2016). Prevalence and monetary costs of dementia in Canada. https://alzheimer.ca/sites/default/files/files/national/statistics/prevalenceandcostsofdemen tia_en.pdf
Anstey, K. J., Luszcz, M. A., & Sanchez, L. (2001). Two-year decline in vision but not hearing is associated with memory decline in very old adults in a population-based sample. Gerontology, 47, 289–293.
Armstrong, R. A. (1996). Visual field defects in Alzheimer's disease patients may reflect differential pathology in the primary visual cortex. Optometry and Vision Science, 73, 677-682.
Avidan, G., Harel, M., Hendler, T., Ben-Bashat, D., Zohary, E., & Malach, R. (2002). Contrast sensitivity in human visual areas and its relationship to object recognition. Journal of Neurophysiology, 87, 3102-3116.
Baltes, P. B., & Lindenberger, U. (1997). Emergence of a powerful connection between sensory and cognitive functions across the adult life span: A new window to the study of cognitive aging? Psychology and Aging, 12, 12–21.
Bambo, M. P., Garcia-Martin, E., Pinilla, J., Herrero, R., Satue, M., Otin, S., ... Pablo, L. E. (2014). Detection of retinal nerve fiber layer degeneration in patients with Alzheimer’s disease using optical coherence tomography: Searching new biomarkers. Acta Ophthalmologica, 92, 581–582. https://doi.org/10.1111/aos.12374
Baron, J. C., Chetelat, G., Desgranges, B., Perchey, G., Landeau, B., De La Sayette, V., & Eustache, F. (2001). In vivo mapping of gray matter loss with voxel-based morphometry in mild Alzheimer's disease. NeuroImage, 14, 298-309.
Bassi, C. J., Solomon, K., & Young, D. (1993). Vision in aging and dementia. Optometry and Vision Science, 70, 809-813.
Baum, L. W. (2005). Sex, hormones, and Alzheimer's disease. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 60, 736-743.
Bayer, A. U., & Ferrari, F. (2002). Severe progression of glaucomatous optic neuropathy in patients with Alzheimer’s Disease. Eye, 16, 209–212.
Bejanin, A., Schonhaut, D. R., La Joie, R., Kramer, J. H., Baker, S. L., Sosa, N., ... & O’Neil, J. P. (2017). Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer’s disease. Brain, 140, 3286-3300.
Berisha, F., Feke, G. T., Trempe, C. L., McMeel, J. W., & Schepens, C. L. (2007). Retinal abnormalities in early Alzheimer’s disease. Investigative Ophthalmology and Visual Science, 48, 2285–2289.
Blanks, J. C., Hinton, D. R., Sadun, A. A., & Miller, C. A. (1989). Retinal ganglion cell degeneration in Alzheimer’s disease. Brain Research, 501, 364–372.
Blanks, J. C., Torigoe, Y., Hinton, D. R., & Blanks, R. H. I. (1996a). Retinal pathology in Alzheimer’s disease. I. Ganglion cell loss in foveal/parafoveal retina. Neurobiology of Aging, 17, 377–384.
Blanks, J. C., Schmidt, S. Y., Torigoe, Y., Porrello, K. V., Hinton, D. R., & Blanks, R. H. I. (1996b). Retinal pathology in Alzheimer’s disease. II. Regional neuron loss and glial changes in GCL. Neurobiology of Aging, 17, 385–395.
Bola, M., Gall, C., & Sabel, B. A. (2015). Disturbed temporal dynamics of brain synchronization in vision loss. Cortex, 67, 134–146.
Boucard, C. C., Hernowo, A. T., Maguire, R. P., Jansonius, N. M., Roerdink, J. B. T. M., Hooymans, J. M. M., & Cornelissen, F. W. (2009). Changes in cortical grey matter density associated with long-standing retinal visual field defects. Brain: A Journal of Neurology, 132, 1898–1906.
Bourne, R. R. A., Flaxman, S. R., Braithwaite, T., Cicinelli, M. V., Das, A., Jonas, J. B., ... Zheng, Y. (2017). Magnitude, temporal trends, and projections of the global prevalence
of blindness and distance and near vision impairment: a systematic review and meta-
analysis. The Lancet Global Health, 5, 888–897.
Bowen, M., Edgar, D. F., Hancock, B., Haque, S., Shah, R., Buchanan, S., ... O’Leary, N.
(2016). The Prevalence of Visual Impairment in People with Dementia (the PrOVIDe study): A cross-sectional study of people aged 60–89 years with dementia and qualitative exploration of individual, carer and professional perspectives. Health Services and Delivery Research, 4, 1–200.
Bozdogan, H. (1987). Model selection and Akaike's Information Criterion (AIC): The general theory and its analytical extensions. Psychometrika, 52, 345–370.
Brenowitz, W. D., Kaup, A. R., Lin, F. R., & Yaffe, K. (2019). Multiple sensory impairment is associated with increased risk of dementia among black and white older adults. Journals of Gerontology - Series A: Biological Sciences and Medical Sciences, 74, 890–896.
Brewer, A. A., & Barton, B. (2014). Visual cortex in aging and Alzheimer's disease: changes in visual field maps and population receptive fields. Frontiers in Psychology, 5, 74.
Burge, W. K., Griffis, J. C., Nenert, R., Elkhetali, A., Decarlo, D. K., Ver Hoef, L. W., ... Visscher, K. M. (2016). Cortical thickness in human V1 associated with central vision loss. Scientific Reports, 6, 1–10.
Chen, S. P., Bhattacharya, J., & Pershing, S. (2017). Association of vision loss with cognition in older adults. JAMA Ophthalmology, 135, 963–970.
Chen, W. W., Wang, N., Cai, S., Fang, Z., Yu, M., Wu, Q., ... Gong, Q. (2013). Structural brain abnormalities in patients with primary open-angle glaucoma: A study with 3T MR imaging. Investigative Ophthalmology and Visual Science, 54, 545–554.
Chertkow, H., Borrie, M., Whitehead, V., Black, S. E., Feldman, H. H., Gauthier, S., ... & Tierney, M. C. (2019). The comprehensive assessment of neurodegeneration and dementia: Canadian cohort study. Canadian Journal of Neurological Sciences, 46, 499- 511.
Chételat, G., Villemagne, V. L., Villain, N., Jones, G., Ellis, K. A., Ames, D., ... & Rowe, C. C. (2012). Accelerated cortical atrophy in cognitively normal elderly with high β-amyloid deposition. Neurology, 78, 477-484.
Choi, S., Jahng, W. J., Park, S. M., & Jee, D. (2020). Association of age-related macular degeneration on Alzheimer or Parkinson Disease: A retrospective cohort study. American Journal of Ophthalmology, 210, 41–47.
Chriqui, E., Law, C., Kergoat, M. J., Leclerc, B. S., & Kergoat, H. (2017). Visual impairment in older institutionalised Canadian seniors with dementia. Ophthalmic and Physiological Optics, 37, 225–233.
Clemons, T. E., Rankin, M. W., & McBee, W. L. (2006). Cognitive impairment in the Age- Related Eye Disease Study: AREDS Report No. 16. Archives of Ophthalmology, 124, 537-543.
Colenbrander, A. (2005). Reading acuity—an important parameter of reading performance. International Congress Series, 1282, 487-491.
Coppola, G., Di Renzo, A., Ziccardi, L., Martelli, F., Fadda, A., Manni, G., ... Parisi, V. (2015). Optical coherence tomography in Alzheimer’s disease: A meta-analysis. PLoS ONE, 10, 1–14.
Cormack, F. K., Tovee, M., & Ballard, C. (2000). Contrast sensitivity and visual acuity in patients with Alzheimer's disease. International Journal of Geriatric Psychiatry, 15, 614- 620.
Cronin-Golomb, A., Rizzo, J. F., Corkin, S., & Growdon, J. H. (1991a). Visual function in Alzheimer’s disease and normal aging. Annals of the New York Academy of Sciences, 640, 28–35.
Cronin-Golomb, A., Corkin, S., Rizzo, J. F., Cohen, J., Growdon, J. H., & Banks, K. S. (1991b). Visual dysfunction in Alzheimer’s Disease: Relation to normal aging. Annals of Neurology, 29, 41-52.
Cruess, A. F., Gordon, K. D., Bellan, L., Mitchell, S., & Pezzullo, M. L. (2011). The cost of vision loss in Canada. 2. Results. Canadian Journal of Ophthalmology, 46, 315-318.
Dale, A.M., Fischl, B., Sereno, M.I. (1999). Cortical surface-based analysis; I. Segmentation and surface reconstruction. NeuroImage, 9, 179–194.
Danesh-Meyer, H. V., Birch, H., Ku, J. Y., Carroll, S., & Gamble, G. (2006). Reduction of optic nerve fibers in patients with Alzheimer disease identified by laser imaging. Neurology, 67, 1852–1854.
Davies-Kershaw, H., Hackett, R., Cadar, D., Herbert, A., Orrell, M., & Steptoe, A. (2018). Vision impairment and risk of dementia: Findings from the English Longitudinal Study of Ageing. Journal of the American Geriatrics Society, 66, 1823-1829.
Destrieux, C., Fischl, B., Dale, A., & Halgren, E. (2010). Automatic parcellation of human cortical gyri and sulci using standard anatomical nomenclature. NeuroImage, 53, 1-15.
Dickerson, B. C., Bakkour, A., Salat, D. H., Feczko, E., Pacheco, J., Greve, D. N., Grodstein, F., Wright, C. I., Blacker, D., Rosas, H. D., Sperling, R. A., Atri, A., Growdon, J. H.,
Hyman, B. T., Morris, J. C., Fischl, B., & Buckner, R. L. (2009). The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals. Cerebral Cortex, 19, 497–510.
Dougerty, B.E., Flom, R. E., & Bullimore, M.A. (2005). An evaluation of the Mars Letter Contrast Sensitivity Test. Optometry and Vision Science, 82, 970-975.
Duncan, R. O. & Boynton, G. M. (2003). Cortical magnification within human primary visual cortex correlates with acuity thresholds. Neuron, 38, 659-671.
Elyashiv, S. M., Shabtai, E. L., & Belkin, M. (2014). Correlation between visual acuity and cognitive functions. British Journal of Ophthalmology, 98, 129–132.
Fischer, M. E., Cruickshanks, K. J., Schubert, C. R., Pinto, A. A., Carlsson, C. M., Klein, B. E. K., ... Tweed, T. S. (2016). Age-related sensory impairments and risk of cognitive impairment. Journal of the American Geriatrics Society, 64, 1981–1987.
Fischl, B., Dale, A.M., 2000. Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proceedings of the National Academy of Sciences of the United States of America, 97, 11050–11055.
Fischl, B., Van Der Kouwe, A., Destrieux, C., Halgren, E., Ségonne, F., Salat, D.H., Busa, E., Caviness, V., Makris, N., Rosen, B., Dale, A.M. (2004). Automatically parcellating the human cerebral cortex. Cerebral Cortex, 14, 11–22.
Fjell, A. M., Westlye, L. T., Amlien, I., Espeseth, T., Reinvang, I., Raz, N., ... Walhovd, K. B. (2009). High consistency of regional cortical thinning in aging across multiple samples. Cerebral Cortex, 19, 2001–2012.
Fox, N. C., Crum, W. R., Scahill, R. I., Stevens, J. M., Janssen, J. C., & Rossor, M. N. (2001). Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images. The Lancet, 358, 201-205.
Friedman, R. B., Ferguson, S., Robinson, S., & Sunderland, T. (1992). Dissociation of mechanisms of reading in Alzheimer's disease. Brain and Language, 43, 400-413.
Frisoni, G. B., Pievani, M., Testa, C., Sabattoli, F., Bresciani, L., Bonetti, M., ... & Thompson, P. M. (2007). The topography of grey matter involvement in early and late onset Alzheimer's disease. Brain, 130, 720-730.
Gates, G. A., Anderson, M. L., Feeney, M. P., McCurry, S. M., & Larson, E. B. (2008). Central auditory dysfunction in older persons with memory impairment or Alzheimer dementia. Archives of Otolaryngology, 134, 771–777.
Gates, G. A., Beiser, A., Rees, T. S., D’Agostino, R. B., & Wolf, P. A. (2002). Central auditory dysfunction may precede the onset of clinical dementia in people with probable Alzheimer’s disease. Journal of the American Geriatrics Society, 50, 482–488.
Gates, G. A., Anderson, M. L., McCurry, S. M., Feeney, M. P., & Larson, E. B. (2011). Central auditory dysfunction as a harbinger of Alzheimer’s dementia. Archives of Otolaryngology, 137, 390-395.
Gili, T., Cercignani, M., Serra, L., Perri, R., Giove, F., Maraviglia, B., ... & Bozzali, M. (2011). Regional brain atrophy and functional disconnection across Alzheimer's disease evolution. Journal of Neurology, Neurosurgery & Psychiatry, 82, 58-66.
Gilmore, G. C., & Whitehouse, P. J. (1995). Contrast sensitivity in Alzheimer's disease: a 1-year longitudinal analysis. Optometry and Vision Science, 72, 83-91.
Glosser, G., Baker, K. M., de Vries, J. J., Alavi, A., Grossman, M., & Clark, C. M. (2002). Disturbed visual processing contributes to impaired reading in Alzheimer’s disease. Neuropsychologia, 40, 902-909.
Gordon, K. D., Cruess, A. F., Bellan, L., Mitchell, S., & Pezzullo, M. L. (2011). The cost of vision loss in Canada. 1. Methodology. Canadian Journal of Ophthalmology, 46, 310– 314.
Griffis, J. C., Burge, W. K., & Visscher, K. M. (2016). Age-dependent cortical thinning of peripheral visual field representations in primary visual cortex. Frontiers in Aging Neuroscience, 8, 1–7.
Hajek, A., Brettschneider, C., Lühmann, D., Eisele, M., Mamone, S., Wiese, B., ... & Riedel‐ Heller, S. G. (2016). Effect of visual impairment on physical and cognitive function in old age: Findings of a population‐based prospective cohort study in Germany. Journal of the American Geriatrics Society, 64, 2311-2316.
Han, J. H., Lee, H. J., Jung, J., & Park, E. C. (2018). Effects of self-reported hearing or vision impairment on depressive symptoms: a population-based longitudinal study. Epidemiology and Psychiatric Sciences, 28, 343-355.
Harrabi, H., Kergoat, M. J., Rousseau, J., Boisjoly, H., Schmaltz, H., Moghadaszadeh, S., ... Freeman, E. E. (2015). Age-related eye disease and cognitive function. Investigative Ophthalmology and Visual Science, 56, 1217–1221.
Harwood, R. H. (2001). Visual problems and falls. Age and Ageing, 30, 13–18. Hassell, J. B., Lamoureux, E. L., & Keeffe, J. E. (2006). Impact of age-related macular
degeneration on quality of life. British Journal of Ophthalmology, 90, 593–596.
Henderson, V. W., Mack, W., & Williams, B. W. (1989). Spatial disorientation in Alzheimer's disease. Archives of Neurology, 46, 391-394.
Hernowo, A. T., Prins, D., Baseler, H. A., Plank, T., Gouws, A. D., Hooymans, J. M. M., ... Cornelissen, F. W. (2014). Morphometric analyses of the visual pathways in macular degeneration. Cortex, 56, 99–110.
Hinton, D. R., Sadun, A. A., Blanks, J. C., & Miller, C. A. (1986). Optic-nerve degeneration in Alzheimer's disease. New England Journal of Medicine, 315, 485-487.
Hong, T., Mitchell, P., Burlutsky, G., Liew, G., & Wang, J. J. (2016). Visual impairment, hearing loss and cognitive function in an older population: longitudinal findings from the Blue Mountains Eye Study. PLoS ONE, 11.
Hua, X., Leow, A. D., Lee, S., Klunder, A. D., Toga, A. W., Lepore, N., ... & Jack Jr, C. R. (2008). 3D characterization of brain atrophy in Alzheimer's disease and mild cognitive impairment using tensor-based morphometry. NeuroImage, 41, 19-34.
Hughes, C. P., Berg, L., Danziger, W., Coben, L. A., & Martin, R. L. (1982). A new clinical scale for the staging of dementia. The British Journal of Psychiatry, 140, 566-572.
Hutton, J. T., Morris, J. L., Elias, J. W., & Poston, J. N. (1993). Contrast sensitivity dysfunction in Alzheimer’s disease. Neurology, 43, 2328–2330.
Ikram, M. K., Cheung, C. Y., Wong, T. Y., & Chen, C. P. L. H. (2012). Retinal pathology as biomarker for cognitive impairment and Alzheimer’s disease. Journal of Neurology, Neurosurgery and Psychiatry, 83, 917–922.
Iseki, E., Matsushita, M., Kosaka, K., Kondo, H., Ishii, T., & Amano, N. (1989). Distribution and morphology of brain stem plaques in Alzheimer's disease. Acta Neuropathologica, 78, 131-136.
Jefferis, J. M., Collerton, J., Taylor, J. P., Jagger, C., Kingston, A., Davies, K., ... Clarke, M. P. (2012). The impact of visual impairment on mini-mental state examination scores in the Newcastle 85+ study. Age and Ageing, 41, 565–568.
Jessen, F., Amariglio, R. E., Buckley, R. F., van der Flier, W. M., Han, Y., Molinuevo, J. L., ... Wagner, M. (2020). The characterisation of subjective cognitive decline. The Lancet Neurology, 4422, 1–8.
Jessen, F., Amariglio, R. E., Van Boxtel, M., Breteler, M., Ceccaldi, M., Chételat, G., ... Wagner, M. (2014). A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease and Subjective Cognitive Decline Initiative (SCD-I). Alzheimer’s & Dementia, 10, 844–852.
Johnson, L. V., Leitner, W. P., Rivest, A. J., Staples, M. K., Radeke, M. J., & Anderson, D. H. (2002). The Alzheimer’s Aβ-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration. Proceedings of the National Academy of Sciences of the United States of America, 99, 11830–11835.
Jorge, L., Canário, N., Quental, H., Bernardes, R., & Castelo-Branco, M. (2020). Is the retina a mirror of the aging brain? Aging of neural retina layers and primary visual cortex across the lifespan. Frontiers in Aging Neuroscience, 11, 1–12.
Karas, G. B., Scheltens, P., Rombouts, S. A. R. B., Visser, P. J., Van Schijndel, R. A., Fox, N. C., & Barkhof, F. (2004). Global and local gray matter loss in mild cognitive impairment and Alzheimer's disease. NeuroImage, 23, 708-716.
Keenan, T. D. L., Goldacre, R., Goldacre, M. J., & Hyman, L. (2014). Associations between age- related macular degeneration, alzheimer disease, and dementia: Record linkage study of hospital admissions. JAMA Ophthalmology, 132, 63–68.
Kesler, A., Vakhapova, V., Korczyn, A. D., Naftaliev, E., & Neudorfer, M. (2011). Retinal thickness in patients with mild cognitive impairment and Alzheimer’s disease. Clinical Neurology and Neurosurgery, 113, 523–526.
Kessing, L. V., Lopez, A. G., Andersen, P. K., & Kessing, S. V. (2007). No increased risk of developing Alzheimer disease in patients with glaucoma. Journal of Glaucoma, 16, 47– 51.
Kirbas, S., Turkyilmaz, K., Anlar, O., Tufekci, A., & Durmus, M. (2013). Retinal nerve fiber layer thickness in patients with Alzheimer disease. Journal of Neuro-Ophthalmology, 33, 58–61.
Kiuchi, K., Kitamura, S., Taoka, T., Yasuno, F., Tanimura, M., Matsuoka, K., Ikawa, D., Toritsuka, M., Hashimoto, K., Makinodan, M., Kosaka, J., Morikawa, M., Kichikawa, K., & Kishimoto, T. (2014). Gray and white matter changes in subjective cognitive impairment, amnestic mild cognitive impairment and Alzheimer's disease: a voxel-based analysis study. PloS ONE, 9.
Kiyosawa, M., Bosley, T., & Chawluk, J. (1989). Alzheimer’s Disease with prominent visual symptoms. Ophthalmology, 96, 1077–1086.
Klaver, C. C., Ott, A., Hofman, A., Assink, J. J., Breteler, M. M., & de Jong, P. T. (1999). Is age- related maculopathy associated with Alzheimer’s Disease? American Journal of Epidemiology, 150, 963–968.
Kline, R. B. (2016). Principles and practice of structural equation modeling (4th ed.). New York, NY: The Guilford Press.
Kulmala, J., Viljanen, A., Sipilä, S., Pajala, S., Pärssinen, O., Kauppinen, M., ... Rantanen, T. (2009). Poor vision accompanied with other sensory impairments as a predictor of falls in older women. Age and Ageing, 38, 162–167.
Kurylo, D. D., Corkin, S., & Growdon, J. H. (1994). Perceptual organization in Alzheimer’s disease. Psychology and Aging, 9(4), 562–567.
Kusne, Y., Wolf, A. B., Townley, K., Conway, M., & Peyman, G. A. (2017). Visual system manifestations of Alzheimer’s disease. Acta Ophthalmologica, 95, 668–676.
Lai, S. W., Lin, C. L., & Liao, K. F. (2017). Glaucoma may be a non-memory manifestation of Alzheimer’s disease in older people. International Psychogeriatrics, 29, 1535–1541.
Lemaitre, H., Goldman, A., & Sambataro, F. (2012). Normal age-related brain morphometric changes: Nonuniformity across cortical thickness, surface area and grey matter volume? Neurobiology of Aging, 33, 1–15.
Leuba, G., & Saini, K. (1995). Pathology of subcortical visual centres in relation to cortical degeneration in Alzheimer's disease. Neuropathology and Applied Neurobiology, 21, 410-422.
Lewis, D. A., Campbell, M. J., Terry, R. D., & Morrison, J. H. (1987). Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices. Journal of Neuroscience, 7, 1799-1808.
Liem, F., Mérillat, S., Bezzola, L., Hirsiger, S., Philipp, M., Madhyastha, T., Jäncke, L. (2015). Reliability and statistical power analysis of cortical and subcortical FreeSurfer metrics in a large sample of healthy elderly. NeuroImage, 108, 95–109.
Lin, F. R., Ferrucci, L., An, Y., Goh, J. O., Doshi, J., Metter, E. J., ... Resnick, S. M. (2014). Association of hearing impairment with brain volume changes in older adults. NeuroImage, 90, 84–92.
Lin, F. R., Hazzard, W. R., & Blazer, D. G. (2016). Priorities for improving hearing health care for adults: A report from the national academies of sciences, engineering, and medicine. Journal of the American Medical Association, 316, 819–820.
Lin, F. R., Metter, E. J., O’Brien, R. J., Resnick, S. M., Zonderman, A. B., & Ferrucci, L. (2011). Hearing loss and incident dementia. Archives of Neurology, 68, 214–220.
Lin, M. Y., Gutierrez, Ã. P. R., Stone, K. L., Yaffe, K., Ensrud, K. E., Fink, H. A., ... Mangione, C. M. (2004). Vision impairment and combined vision and hearing impairment predict cognitive and functional decline in older women. American Journal of Public Health, 1996–2002.
Lindenberger, U., & Baltes, P. B. (1994). Sensory functioning and intelligence in old age: A strong connection. Psychology and Aging, 9, 339–355.
Livingston, G., Sommerlad, A., Orgeta, V., Costafreda, S. G., Huntley, J., Ames, D., ... Mukadam, N. (2017). Dementia prevention, intervention, and care. The Lancet, 6736, 1– 62.
Lou, A. R., Madsen, K. H., Julian, H. O., Toft, P. B., Kjaer, T. W., Paulson, O. B., ... & Siebner, H. R. (2013). Postoperative increase in grey matter volume in visual cortex after unilateral cataract surgery. Acta Ophthalmologica, 91, 58-65.
Lu, Y., Li, Z., Zhang, X., Ming, B., Jia, J., Wang, R., & Ma, D. (2010). Retinal nerve fiber layer structure abnormalities in early Alzheimer’s disease: Evidence in optical coherence tomography. Neuroscience Letters, 480, 69–72.
Luo, Y., He, P., Guo, C., Chen, G., Li, N., & Zheng, X. (2018). Association between sensory impairment and dementia in older adults: Evidence from China. Journal of American Geriatrics, 66, 480-486.
Mandal, P. K., Joshi, J., & Saharan, S. (2012). Visuospatial perception: An emerging biomarker for Alzheimer’s disease. Journal of Alzheimer’s Disease, 31, 117-135.
Mann, D. M. A. (1991). The topographic distribution of brain atrophy in Alzheimer's disease. Acta Neuropathologica, 83, 81-86.
Mansfield, J. S., Legge, G. E., Luebker, A., & Cunningham, K. (1994). MNREAD Acuity Charts: continuous-text reading-acuity charts for normal and low vision. Long Island City, NY: Lighthouse Low Vision Products.
Marquie, M., Castilla-Martí, M., Valero, S., Martínez, J., Sánchez, D., Hernández, I., ... Boada, M. (2019). Visual impairment in aging and cognitive decline: experience in a Memory Clinic. Scientific Reports, 9, 1–10.
McCarty, C. A., Nanjan, M. B., & Taylor, H. R. (2001). Vision impairment predicts 5-year mortality. British Journal of Ophthalmology, 85, 322–326.
McGinnis, S. M., Brickhouse, M., Pascual, B., & Dickerson, B. C. (2011). Age-related changes in the thickness of cortical zones in humans. Brain Topography, 24, 279–291.
McKee, A. C., Au, R., Cabral, H. J., Kowall, N. W., Seshadri, S., Kubilus, C. A., ... & Wolf, P. A. (2006). Visual association pathology in preclinical Alzheimer disease. Journal of Neuropathology & Experimental Neurology, 65, 621-630.
McKhann, G.M., Knopman, D.S., Chertkow, H., Hyman, B.T., Jack, C.R., Kawas, C.H., Klunk, W.E., Koroshetz, W.J., Manly, J.J., Mayeux, R., Mohs, R.C., Morris, J.C., Rossor, M.N., Scheltens, P., Carrillo, M.C., Thies, B., Weintraub, S., Phelps, C.H., 2011. The diagnosis
of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s & Dementia, 7, 263–269.
Mendez, M. F., Cherrier, M. M., & Meadows, R. S. (1996). Depth perception in Alzheimer's disease. Perceptual and Motor Skills, 83, 987-995.
Mick, P., Hämäläinen, A., Kolisang, L., Pichora-Fuller, M., Phillips, N., Guthrie, D., & Wittich, W. (2020). The prevalence of hearing, vision, and dual sensory loss in older Canadians: An analysis of data from the Canadian Longitudinal Study on Aging. Canadian Journal on Aging, 1-22.
Millington, R. S., James-Galton, M., Maia Da Silva, M. N., Plant, G. T., & Bridge, H. (2017). Lateralized occipital degeneration in posterior cortical atrophy predicts visual field deficits. NeuroImage, 14, 242–249.
Mine, M., Miyata, K., Morikawa, M., Nishi, T., Okamoto, N., Kawasaki, R., ... & Ogata, N. (2016). Association of visual acuity and cognitive impairment in older individuals: Fujiwara-kyo Eye study. BioResearch Open Access, 5, 228-234.
Monge, Z. A., & Madden, D. J. (2016). Linking cognitive and visual perceptual decline in healthy aging: The information degradation hypothesis. Neuroscience and Biobehavioral Reviews, 69, 166–173.
Morris, J. C., Heyman, A., Mohs, R. C., Hughes, J. P., van Belle, G., Fillenbaum, G. D. M. E., ... & Clark, C. (1989). The consortium to establish a registry for Alzheimer's disease (CERAD): I. Clinical and neuropsychological assessment of Alzheimer's
disease. Neurology, 39, 1159-1165.
Mouton, P. R., Martin, L. J., Calhoun, M. E., Dal Forno, G., & Price, D. L. (1998). Cognitive decline strongly correlates with cortical atrophy in Alzheimer’s dementia. Neurobiology of Aging, 19, 371-377.
Murphy, M. C., Conner, I. P., Teng, C. Y., Lawrence, J. D., Safiullah, Z., Wang, B., ... Chan, K. C. (2016). Retinal structures and visual cortex activity are impaired prior to clinical vision loss in glaucoma. Scientific Reports, 6, 1–11.
Naël, V., Pérès, K., Dartigues, J. F., Letenneur, L., Amieva, H., Arleo, A., ... von Hanno, T. (2019). Vision loss and 12-year risk of dementia in older adults: the 3C cohort study. European Journal of Epidemiology, 34, 141–152.
Nasreddine, Z.S., Phillips, N.A., Bédirian, V., Charbonneau, S., Whitehead, V., Collin, I., Cummings, J.L., Chertkow, H., 2005. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. Journal of the American Geriatrics Society, 53, 695–699.
Nishioka, C., Poh, C., & Sun, S. (2017). Diffusion tensor imaging reveals visual pathway damage in patients with mild cognitive impairment and Alzheimer’s Disease. Physiology & Behavior, 176, 139–148.
Nissen, M. J., Corkin, S., Buonanno, F. S., Growdon, J. H., Wray, S. H., & Bauer, J. (1985). Spatial vision in Alzheimer's disease: general findings and a case report. Archives of Neurology, 42, 667-671.
Obara, K., Meyer, J. S., Mortel, K. F., & Muramatsu, K. (1994). Cognitive declines correlate with decreased cortical volume and perfusion in dementia of Alzheimer type. Journal of the Neurological Sciences, 127, 96-102.
Ohno-Matsui, K. (2011). Parallel findings in age-related macular degeneration and Alzheimer’s disease. Progress in Retinal and Eye Research, 30, 217–238.
Ong, S. Y., Cheung, C. Y., Li, X., Lamoureux, E. L., Ikram, M. K., Ding, J., ... Wong, T. Y. (2012). Visual impairment, age-related eye diseases, and cognitive function: The Singapore Malay Eye Study. Archives of Ophthalmology, 130, 895–900.
Pache, M., Smeets, C. H. W., Gasio, P. F., Savaskan, E., Flammer, J., Wirz-Justice, A., & Kaiser, H. J. (2003). Colour vision deficiencies in Alzheimer’s disease. Age and Ageing, 32, 422–426.
Paquet, C., Boissonnot, M., Roger, F., Dighiero, P., Gil, R., & Hugon, J. (2007). Abnormal retinal thickness in patients with mild cognitive impairment and Alzheimer’s disease. Neuroscience Letters, 420, 97–99.
Pascolini, D., & Mariotti, S. P. (2012). Global estimates of visual impairment: 2010. British Journal of Ophthalmology, 96, 614-618.
Pennanen, C., Testa, C., Laakso, M. P., Hallikainen, M., Helkala, E. L., Hänninen, T., ... & Vanhanen, M. (2005). A voxel based morphometry study on mild cognitive impairment. Journal of Neurology, Neurosurgery & Psychiatry, 76, 11-14.
Petersen, R. C. (2011). Mild cognitive impairment. The England Journal of Medicine, 364, 2227–2234.
Pham, T. Q., Kifley, A., Mitchell, P., & Wang, J. J. (2006). Relation of age-related macular degeneration and cognitive impairment in an older population. Gerontology, 52, 353-358.
Plank, T., Frolo, J., Brandl-Rühle, S., Renner, A. B., Hufendiek, K., Helbig, H., & Greenlee, M. W. (2011). Gray matter alterations in visual cortex of patients with loss of central vision due to hereditary retinal dystrophies. NeuroImage, 56, 1556–1565.
Popescu, M. L., Boisjoly, H., Schmaltz, H., Kergoat, M. J., Rousseau, J., Moghadaszadeh, S., ... Freeman, E. E. (2011). Age-related eye disease and mobility limitations in older adults. Investigative Ophthalmology and Visual Science, 52, 7168–7174.
Prins, D., Jansonius, N. M., & Cornelissen, F. W. (2017). Loss of binocular vision in monocularly blind patients causes selective degeneration of the superior lateral occipital cortices. Investigative Ophthalmology and Visual Science, 58, 1304–1313.
Reyes-Ortiz, C. A., Kuo, Y. F., DiNuzzo, A. R., Ray, L. A., Raji, M. A., & Markides, K. S. (2005). Near vision impairment predicts cognitive decline: Data from the Hispanic established populations for epidemiologic studies of the elderly. Journal of the American Geriatrics Society, 53, 681–686.
Risacher, S. L., WuDunn, D., Pepin, S. M., MaGee, T. R., McDonald, B. C., Flashman, L. A., ... Saykin, A. J. (2013). Visual contrast sensitivity in Alzheimer’s disease, mild cognitive impairment, and older adults with cognitive complaints. Neurobiology of Aging, 34, 1133–1144.
Rizzo, M., & Nawrot, M. (1998). Perception of movement and shape in Alzheimer’s disease. Brain, 121(12), 2259–2270.
Rizzo, M., Anderson, S. W., Dawson, J., & Nawrot, M. (2000). Vision and cognition in Alzheimer’s disease. Neuropsychologia, 38, 1157–1169.
Rogers, M. A. M., & Langa, K. M. (2010). Untreated poor vision: A contributing factor to late- life dementia. American Journal of Epidemiology, 171, 728–735.
Rong, S. S., Lee, B. Y., Kuk, A. K., Yu, X. T., Li, S. S., Li, J., ... Ng, D. S. C. (2019). Comorbidity of dementia and age-related macular degeneration calls for clinical awareness: a meta-analysis. British Journal of Ophthalmology, 103, 1777–1783.
Sachdev, P. S., Lipnicki, D. M., Crawford, J., Reppermund, S., Kochan, N. A., Trollor, J. N., ... Brodaty, H. (2012). Risk profiles of subtypes of mild cognitive impairment: The Sydney Memory and Ageing Study. Journal of the American Geriatrics Society, 60, 24–33.
Sadun, A. A., & Bassi, C. J. (1990). Optic nerve damage in Alzheimer's disease. Ophthalmology, 97, 9-17.
Salamone, G., Di Lorenzo, C., Mosti, S., Lupo, F., Cravello, L., Palmer, K., ... & Caltagirone, C. (2009). Color discrimination performance in patients with Alzheimer’s disease. Dementia and Geriatric Cognitive Disorders, 27, 501-507.
Salat, D. H., Buckner, R. L., Snyder, A. Z., Greve, D. N., Desikan, R. S. R., Busa, E., ... Fischl, B. (2004). Thinning of the cerebral cortex in aging. Cerebral Cortex, 14, 721–730.
Scilley, K., Jackson, G. R., Cideciyan, A. V., Maguire, M. G., Jacobson, S. G., & Owsley, C. (2002). Early age-related maculopathy and self-reported visual difficulty in daily
life. Ophthalmology, 109, 1235-1242.
Spear, P. D. (1993). Neural bases of visual deficits during aging. Vision Research, 33, 2589– 2609.
Spierer, O., Fischer, N., Barak, A., & Belkin, M. (2016). Correlation between vision and cognitive function in the elderly: A cross-sectional study. Medicine, 95, 1–5.
Strain, E., Patterson, K., Graham, N., & Hodges, J. R. (1998). Word reading in Alzheimer's disease: Cross-sectional and longitudinal analyses of response time and accuracy data. Neuropsychologia, 36, 155-171.
Swenor, B. K., Lee, M. J., Tian, J., Varadaraj, V., & Bandeen-Roche, K. (2020). Visual impairment and frailty: Examining an understudied relationship. The Journals of Gerontology: Series A: Biological Sciences and Medical Sciences, 75, 596–602.
Swenor, B. K., Wang, J., Varadaraj, V., Rosano, C., Yaffe, K., Albert, M., ... Magaziner, J. (2019). Vision impairment and cognitive outcomes in older adults: The Health ABC Study. Journals of Gerontology - Series A: Biological Sciences and Medical Sciences, 74, 1454–1460.
Tamura, H., Kawakami, H., Kanamoto, T., Kato, T., Yokoyama, T., Sasaki, K., ... Mishima, H. K. (2006). High frequency of open-angle glaucoma in Japanese patients with Alzheimer’s disease. Journal of the Neurological Sciences, 246, 79–83.
Thambisetty, M. (2008). Longitudinal changes in cortical thickness associated with normal aging. Bone, 23, 1–7.
Tzekov, R., & Mullan, M. (2014). Vision function abnormalities in Alzheimer disease. Survey of Ophthalmology, 59, 414-433.
Uhlmann, R. F., Larson, E. B., Koepsell, T. D., Rees, T. S., & Duckert, L. G. (1991). Visual impairment and cognitive dysfunction in Alzheimer’s disease. Journal of General Internal Medicine, 6, 126–132.
Valenti, D. A. (2010). Alzheimer’s disease and glaucoma: Imaging the biomarkers of neurodegenerative disease. International Journal of Alzheimer’s Disease, 2010, 1-9.
Valentijn, S. A., Van Boxtel, M. P., Van Hooren, S. A., Bosma, H., Beckers, H. J., Ponds, R. W., & Jolles, J. (2005). Change in sensory functioning predicts change in cognitive functioning: Results from a 6‐year follow‐up in the Maastricht Aging Study. Journal of the American Geriatrics Society, 53, 374-380.
Varin, M., Kergoat, M. J., Belleville, S., Li, G., Rousseau, J., Roy-Gagnon, M. H., ... Freeman, E. E. (2017). Age-related eye disease and participation in cognitive activities. Scientific Reports, 7, 7–11.
Varin, M., Kergoat, M. J., Belleville, S., Li, G., Rousseau, J., Roy-Gagnon, M. H., ... Freeman, E. E. (2019). Age-related eye disease and cognitive function: The search for mediators. Ophthalmology, 127, 660-666.
Verghese, J., LeValley, A., Derby, C., Kuslansky, G., Katz, M., Hall, C., ... Lipton, R. B. (2006). Leisure activities and the risk of amnestic mild cognitive impairment in the elderly. Neurology, 66, 821–827.
Voevodskaya, O., Simmons, A., Nordenskjöld, R., Kullberg, J., Ahlström, H., Lind, L., Wahlund, L.-O., Larsson, E.-M., Westman, E. (2014). The effects of intracranial volume adjustment approaches on multiple regional MRI volumes in healthy aging and Alzheimer’s disease. Frontiers in Aging Neuroscience, 6, 1-14.
Vu, H. T. V., Keeffe, J. E., McCarty, C. A., & Taylor, H. R. (2005). Impact of unilateral and bilateral vision loss on quality of life. British Journal of Ophthalmology, 89, 360–363.
Ward, M. E., Gelfand, J. M., Lui, L. Y., Ou, Y., Green, A. J., Stone, K., ... Yaffe, K. (2018). Reduced contrast sensitivity among older women is associated with increased risk of cognitive impairment. Annals of Neurology, 83, 730–738.
Wechsler, D. Wechsler Memory Scale - Revised. San Antonio: The Psychological Corporation; 1987.
Whitson, H. E., Cousins, S. W., Burchett, B. M., Hybels, C. F., Pieper, C. F., & Cohen, H. J. (2007). The combined effect of visual impairment and cognitive impairment on disability in older people. Journal of the American Geriatrics Society, 55, 885–891.
Whitwell, J. L. (2010). Progression of atrophy in Alzheimer’s disease and related disorders. Neurotoxicity Research, 18, 339-346.
Wichmann, W., & Müller-Forell, W. (2004). Anatomy of the visual system. European Journal of Radiology, 49, 8-30.
Williams, M. A., McGowan, A. J., Cardwell, C. R., Cheung, C. Y., Craig, D., Passmore, P., ... McKay, G. J. (2015). Retinal microvascular network attenuation in Alzheimer’s disease. Alzheimer’s and Dementia: Diagnosis, Assessment and Disease Monitoring, 1, 229–235.
Woo, S. J., Park, K. H., Ahn, J., Choe, J. Y., Jeong, H., Han, J. W., ... Kim, K. W. (2012). Cognitive impairment in age-related macular degeneration and geographic atrophy. Ophthalmology, 119, 2094–2101.
World Health Organization. Blindness and Visual Impairment. World Health Organization website. https://www.who.int/news-room/fact-sheets/detail/blindness-and-visual- impairment. Updated October 2019. Accessed January 2020.
Xiang, X., Freedman, V. A., Shah, K., Hu, R. X., Stagg, B. C., & Ehrlich, J. R. (2020). Self- reported Vision Impairment and Subjective Well-being in Older Adults: A Longitudinal Mediation Analysis. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 75, 589–595.
Xiong, Y. Z., Calabrese, A., Cheong, A. M., & Legge, G. E. (2018). Reading acuity as a predictor of low-vision reading performance. Investigative Ophthalmology & Visual Science, 59, 4798-4803.
Zheng, D. D., Swenor, B. K., Christ, S. L., West, S. K., Lam, B. L., & Lee, D. J. (2018). Longitudinal associations between visual impairment and cognitive functioning the Salisbury Eye Evaluation Study. JAMA Ophthalmology, 136, 989–995.
Zhu, Z., Liao, H., Wang, W., Scheetz, J., Zhang, J., & He, M. (2019). Association between age- related macular degeneration and subjective cognitive complaints. British Journal of Ophthalmology, 1–6.
Zijdenbos, A.P., Forghani, R., Evans, A.C., (2002). Automatic “pipeline” analysis of 3-D MRI data for clinical trials: application to multiple sclerosis. IEEE Transactions on Medical Imaging, 21, 1280–1291.
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