Khoo, Shaun Yon-Seng 
ORCID: https://orcid.org/0000-0002-0972-3788, Uhrig, Alexandra, Samaha, Anne-Noël ORCID: https://orcid.org/0000-0001-5546-1910 and Chaudhri, Nadia ORCID: https://orcid.org/0000-0003-4217-4044
(2021)
Effects of dopamine receptor antagonism and amphetamine-induced psychomotor sensitization on sign- and goal-tracking after extended training.
Behavioural Brain Research
.
ISSN 0166-4328
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Official URL: https://doi.org/10.1016/j.bbr.2021.113238
Abstract
The dopamine system is important for incentive salience attribution, where motivational value is assigned to conditioned cues that predict appetitive reinforcers. However, the role of dopamine in this process may change with extended training. We tested the effects of dopamine D1-like and D2-like receptor antagonism on the expression of sign-tracking and goal-tracking conditioned responses following extended Pavlovian conditioned approach (PCA) training. We also tested if amphetamine-induced psychomotor sensitization accelerates the enhanced acquisition of sign-tracking that is observed with extended training. In experiment 1, 24 male Long-Evans rats received 20 PCA sessions in which one lever (CS+, 10 s) predicted 0.2 mL sucrose (10\%, w/v) delivery and the other lever (CS–) did not. SCH-23390 (D1-like antagonist) or eticlopride (D2-like antagonist) were administered before non-reinforced behavioural tests at doses of 0, 0.01, and 0.1 mg/kg (s.c.). In experiment 2, rats received vehicle or 2 mg/kg amphetamine (i.p.) for 7 days (n = 12/group). Ten days later, they received 16 PCA training sessions. Both doses of SCH-23390 reduced sign- and goal-tracking, but also reduced locomotor behaviour. A low dose of eticlopride (0.01 mg/kg) selectively reduced goal-tracking, without affecting sign-tracking or locomotor behaviour. Amphetamine produced psychomotor sensitization, and this did not affect the acquisition of sign- or goal-tracking. Following extended PCA training, dopamine D2-like receptor activity is required for the expression of goal-tracking but not sign-tracking. Psychomotor sensitization to amphetamine did not impact incentive salience attribution; however, more selective manipulations of the dopamine system may be needed.
| Divisions: | Concordia University > Research Units > Centre for Studies in Behavioural Neurobiology |
|---|---|
| Item Type: | Article |
| Refereed: | Yes |
| Authors: | Khoo, Shaun Yon-Seng and Uhrig, Alexandra and Samaha, Anne-Noël and Chaudhri, Nadia |
| Journal or Publication: | Behavioural Brain Research |
| Date: | 17 March 2021 |
| Funders: |
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| Digital Object Identifier (DOI): | 10.1016/j.bbr.2021.113238 |
| Keywords: | Autoshaping; Pavlovian conditioned approach; sign-tracking; SCH-23390; eticlopride; amphetamine |
| ID Code: | 988082 |
| Deposited By: | SHAUN YON-SENG KHOO |
| Deposited On: | 01 Apr 2021 21:23 |
| Last Modified: | 01 Apr 2021 21:23 |
| Related URLs: |
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