Wong, Shiu F., Cardoso, Christopher, Orlando, Mark Anthony, Brown, Christopher A. and Ellenbogen, Mark A. 
ORCID: https://orcid.org/0000-0001-8928-5492
(2021)
Depressive symptoms and social context modulate oxytocin’s effect on negative memory recall.
Social Cognitive and Affective Neuroscience
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ISSN 1749-5024
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Official URL: https://academic.oup.com/scan/advance-article/doi/...
Abstract
Oxytocin promotes social affiliation across various species, in part by altering social cognition to facilitate approach behaviour. However, the effects of intranasal oxytocin on human social cognition are mixed, perhaps because its effects are context-dependent and subject to inter-individual differences. Few studies have included explicit manipulations of social context to test this supposition. We examined oxytocin’s effects on autobiographical memory recall in two contexts, with and without social contact, and evaluated whether these effects were moderated by depressive symptoms. Two non-clinical samples (Study 1 N = 48; Study 2 N = 63) completed randomised, placebo-controlled, within-subject experiments. We assessed autobiographical memory recall across two sessions (intranasal oxytocin or placebo) and two contexts (memories elicited by an experimenter or by computer). Overall, intranasal oxytocin increased ratings of vividness of recalled memories during the social context only. Individuals with elevated depressive symptoms also recalled memories that were more negative following oxytocin relative to placebo only in the non-social context across the two studies. Findings highlight the negative consequences of increasing oxytocin bioavailability in vulnerable persons in the absence of social contact. Contextual factors such as social isolation among depressed populations may complicate the clinical use of oxytocin.
| Divisions: | Concordia University > Faculty of Arts and Science > Psychology |
|---|---|
| Item Type: | Article |
| Refereed: | Yes |
| Authors: | Wong, Shiu F. and Cardoso, Christopher and Orlando, Mark Anthony and Brown, Christopher A. and Ellenbogen, Mark A. |
| Journal or Publication: | Social Cognitive and Affective Neuroscience |
| Date: | 2021 |
| Funders: |
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| Digital Object Identifier (DOI): | 10.1093/scan/nsab072 |
| Keywords: | Intranasal oxytocin; Autobiographical memory; Depression; Social context |
| ID Code: | 989123 |
| Deposited By: | MARK ELLENBOGEN |
| Deposited On: | 18 Nov 2021 17:16 |
| Last Modified: | 18 Nov 2021 17:16 |
References:
Bartz, J. A., Nitschke, J. P., Krol, S. A., & Tellier, P. P. (2019). Oxytocin selectively improves empathic accuracy: A replication in men and novel insights in women. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 4, 1042-1048. doi:10.1016/j.bpsc.2019.01.014Bartz, J. A., Simeon, D., Hamilton, H., Kim, S., Crystal, S., Braun, A., . . . Hollander, E. (2010). Oxytocin can hinder trust and cooperation in borderline personality disorder. Social Cognitive and Affective Neuroscience, 6, 556-563. doi:10.1093/scan/nsq085
Bartz, J. A., Zaki, J., Bolger, N., Hollander, E., Ludwig, N. N., Kolevzon, A., & Ochsner, K. N. (2010). Oxytocin selectively improves empathic accuracy. Psychological Science, 21, 1426-1428. doi:10.1177/0956797610383439
Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011). Social effects of oxytocin in humans: Context and person matter. Trends in Cognitive Sciences, 15, 301-309. doi:10.1016/j.tics.2011.05.002
Bartz, J. A., Zaki, J., Ochsner, K. N., Bolger, N., Kolevzon, A., Ludwig, N. N., & Lydon, J. E. (2010). Effects of oxytocin on recollections of maternal care and closeness. Proceedings of the National Academy of Sciences of the United States of America, 107, 21371-21375. doi:10.1073/pnas.1012669107
Beck, A., Steer, R. A., & Brown, G. K. (1996). Beck Depression Inventory - Second Edition Manual. San Antonio, TX: The Psychological Corporation.
Brown, C., Cardoso, C., & Ellenbogen, M. A. (2016). A meta-analytic review of the correlation between peripheral oxytocin and cortisol concentrations. Frontiers in Neuroendocrinology, 43, 19-27. doi:10.1016/j.yfrne.2016.11.001
Cacioppo, J. T., Hawkley, L. C., & Thisted, R. A. (2010). Perceived social isolation makes me sad: 5-year cross-lagged analyses of loneliness and depressive symptomatology in the Chicago Health, Aging, and Social Relations Study. Psychology and Aging, 25, 453-463. doi:10.1037/a0017216
Cardoso, C., Ellenbogen, M. A., & Linnen, A. M. (2012). Acute intranasal oxytocin improves positive self-perceptions of personality. Psychopharmacology, 220, 741-749. doi:10.1007/s00213-011-2527-6
Cardoso, C., Ellenbogen, M. A., Serravalle, L., & Linnen, A. M. (2013). Stress-induced negative mood moderates the relation between oxytocin administration and trust: Evidence for the tend-and-befriend response to stress? Psychoneuroendocrinology, 38, 2800-2804. doi:10.1016/j.psyneuen.2013.05.006
Cardoso, C., Kalogeropoulos, C., Brown, C., Orlando, M., & Ellenbogen, M. A. (2016). Memory response to oxytocin predicts relationship dissolution over 18 months. Psychoneuroendocrinology, 68, 171-176. doi:10.1016/j.psyneuen.2016.03.005
Cardoso, C., Kingdon, D., & Ellenbogen, M. A. (2014). A meta-analytic review of the impact of intranasal oxytocin adminstration on cortisol concentrations during laboratory tasks: Moderation by method and mental health. Psychoneuroendocrinology, 49, 161-170. doi:10.1016/j.psyneuen.2014.07.014
Cardoso, C., Orlando, M., Brown, C., & Ellenbogen, M. A. (2014). Oxytocin and enhancement of the positive valence of social affiliation memories: An autobiographical memory study. Social Neuroscience, 9, 186-195. doi:10.1080/17470919.2013.873079
Cardoso, C., Valkanas, H., Serravalle, L., & Ellenbogen, M. A. (2016). Oxytocin and social context moderate social support seeking in women during negative memory recall. Psychoneuroendocrinology, 70, 63-69. doi:10.1016/j.psyneuen.2016.05.001
Carter, C. S. (2014). Oxytocin pathways and the evolution of human behavior. Annual Review of Psychology, 65, 17-39. doi:10.1146/annurev-psych-010213-115110
Churchland, P. S., & Winkielman, P. (2012). Modulating social behavior with oxytocin: How does it work? What does it mean? Hormones and Behavior, 61, 392-399. doi:10.1016/j.yhbeh.2011.12.003
Cooper, R. A., Kensinger, E. A., & Ritchey, M. (2019). Memories fade: The relationship between memory vividness and remembered visual salience. Psychological Science, 30, 657-668. doi:10.1177/0956797619836093
De Dreu, C. K. W., Greer, L. L., Van Kleef, G. A., Shalvi, S., & Handgraaf, M. J. J. (2011). Oxytocin promotes human ethnocentrism. Proceedings of the National Academy of Sciences of the United States of America, 108, 1262-1266. doi:10.1073/pnas.1015316108
De Dreu, C. K. W., Shalvi, S., Greer, L. L., Van Kleef, G. A., & Handgraaf, M. J. J. (2012). Oxytocin motivates non-cooperation in intergroup conflict to protect vulnerable in-group members. PloS one, 7, e46751. doi:10.1371/journal.pone.0046751
Declerck, C. H., Boone, C., & Kiyonari, T. (2010). Oxytocin and cooperation under conditions of uncertainty: The modulating role of incentives and social information. Hormones and Behavior, 57, 368-374. doi:10.1016/j.yhbeh.2010.01.006
Declerck, C. H., Boone, C., Pauwels, L., Vogt, B., & Fehr, E. (2020). A registered replication study on oxytocin and trust. Nature Human Behaviour, 4, 646-655. doi:10.1038/s41562-020-0878-x
Di Simplicio, M., Massey-Chase, R., Cowen, P. J., & Harmer, C. J. (2009). Oxytocin enhances the processing of positive versus negative emotional information in healthy male volunteers. Psychopharmacology, 23, 241-248. doi:10.1177/0269881108095705
Ditzen, B., Schaer, M., Gabriel, B., Bodenmann, G., Ehlert, U., & Heinrichs, M. (2009). Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict. Biological Psychiatry, 65, 728-731. doi:10.1016/j.biopsych.2008.10.011
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007). Oxytocin improves "mind-reading" in humans. Biological Psychiatry, 61, 731-733. doi:10.1016/j.biopsych.2006.07.015
Ellenbogen, M. A. (2018). Oxytocin and facial emotion recognition. In R. Hurlemann & V. Grinevich (Eds.), Behavioral pharmacology of neuropeptides: Oxytocin (pp. 349-374). Berlin, DE: Springer International Publishing.
Ellenbogen, M. A., Cardoso, C., Serravalle, L., & Tsekova, V. (2018). T142. Intranasal oxytocin augments the efficacy of psychotherapy for major depressive disorder. Biological Psychiatry, 83, S183.
Ellenbogen, M. A., Linnen, A. M., Cardoso, C., & Joober, R. (2013). Intranasal oxytocin impedes the ability to ignore task-irrelevant facial expressions of sadness in students with depressive symptoms. Psychoneuroendocrinology, 38, 387-398. doi:10.1016/j.psyneuen.2012.06.016
Ellenbogen, M. A., Linnen, A. M., Grumet, R., Cardoso, C., & Joober, R. (2012). The acute effects of intranasal oxytocin on automatic and effortful attentional shifting to emotional faces. Psychophysiology, 49, 128-137. doi:10.1111/j.1469-8986.2011.01278.x
Fischer-Shofty, M., Levkovitz, Y., & Shamay-Tsoory, S. G. (2013). Oxytocin facilitates accurate perception of competition in men and kinship in women. Social Cognitive and Affective Neuroscience, 8, 313-317. doi:10.1093/scan/nsr100
Guastella, A. J., Hickie, I. B., McGuinness, M. M., Otis, M., Woods, E. A., Disinger, H. M., . . . Banati, R. B. (2013). Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research. Psychoneuroendocrinology, 38, 612-625. doi:10.1016/j.psyneuen.2012.11.019
Guastella, A. J., Mitchell, D., & Mathews, F. (2008). Oxytocin enhances the encoding of positive social memories in humans. Biological Psychiatry, 64, 256-258. doi:10.1016/j.biopsych.2008.02.008
Hermans, D., Vandromme, H., Debeer, E., Raes, F., Demyttenaere, K., Brunfaut, E., & Williams, J. M. G. (2008). Overgeneral autobiographical memory predicts diagnostic status in depression. Behaviour Research and Therapy, 46, 668-677. doi:10.1016/j.brat.2008.01.018
Hu, J., Wang, Z., Feng, X., Long, C., & Schiller, D. (2019). Post-retrieval oxytocin facilitates next day extinction of threat memory in humans. Psychopharmacology, 236, 293-301. doi:10.1007/s00213-018-5074-6
Klein, D. N., Glenn, C. R., Kosty, D. B., Seeley, J. R., Rohde, P., & Lewinsohn, P. M. (2013). Predictors of first lifetime onset of major depressive disorder in young adulthood. Journal of Abnormal Psychology, 122, 1-6. doi:10.1037/a0029567
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005). Oxytocin increases trust in humans. Nature, 435, 673-676. doi:10.1038/nature03701
Leng, G., & Ludwig, M. (2016). Intranasal oxytocin: Myths and delusions. Biological Psychiatry, 79, 243-250. doi:10.1016/j.biopsych.2015.05.003
MacDonald, K., MacDonald, T. M., Brüne, M., Lamb, K., Wilson, M. P., Golshan, S., & Feifel, D. (2013). Oxytocin and psychotherapy: A pilot study of its physiological, behavioral and subjective effects in males with depression. Psychoneuroendocrinology, 38, 2831-2843. doi:10.1016/j.psyneuen.2013.05.014
Mah, B. L., Bakermans-Kranenburg, M. J., Van IJzendoorn, M. H., & Smith, R. (2015). Oxytocin promotes protective behavior in depressed mothers: A pilot study with the enthusiastic stranger paradigm. Depression and Anxiety, 32, 76-81. doi:10.1002/da.22245
Mah, B. L., Van IJzendoorn, M. H., Smith, R., & Bakermans-Kranenburg, M. J. (2013). Oxytocin in postnatally depressed mothers: Its influence on mood and expressed emotion. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 40, 267-272. doi:10.1016/j.pnpbp.2012.10.005
Massey, S. H., Backes, K. A., & Schuette, S. A. (2016). Plasma oxytocin concentration and depressive symptoms: A review of current evidence and directions for future research. Depression and Anxiety, 33, 316-322. doi:10.1002/da.22467
Ne'eman, R., Perach-Barzilay, N., Fischer-Shofty, M., Atias, A., & Shamay-Tsoory, S. G. (2016). Intranasal administration of oxytocin increases human aggressive behavior. Hormones and Behavior, 80, 125-131. doi:10.1016/j.yhbeh.2016.01.015
Norman, G. J., Cacioppo, J. T., Morris, J. S., Malarkey, W. B., Berntson, G. G., & DeVries, A. C. (2011). Oxytocin increases autonomic cardiac control: Moderation by loneliness. Biological Psychology, 86, 174-180. doi:10.1016/j.biopsycho.2010.11.006
Paloyelis, Y., Doyle, O. M., Zelaya, F. O., Maltezos, S., Williams, S. C., Fotopoulou, A., & Howard, M. A. (2016). A spatiotemporal profile of in vivo cerebral blood flow changes following intranasal oxytocin in humans. Biological Psychiatry, 79, 693-705. doi:10.1016/j.biopsych.2014.10.005
Parker, K. J., Kenna, H. A., Zeitzer, J. M., Keller, J., Blasey, C. M., Amico, J. A., & Schatzberg, A. F. (2010). Preliminary evidence that plasma oxytocin levels are elevated in major depression. Psychiatry Research, 178, 359-362. doi:10.1016/j.psychres.2009.09.017
Pincus, D., Kose, S., Arana, A., Johnson, K., Morgan, P. S., Borckardt, J., . . . Nahas, Z. (2010). Inverse effects of oxytocin on attributing mental activity to others in depressed and healthy subjects: A double-blind placebo controlled fMRI study. Frontiers in Psychiatry, 1, 134. doi:10.3389/fpsyt.2010.00134
Pivik, R., Broughton, R., Coppola, R., Davidson, R., Fox, N., & Nuwer, M. (1993). Guidelines for the recording and quantitative analysis of electroencephalographic activity in research contexts. Psychophysiology, 30, 547-558. doi:10.1111/j.1469-8986.1993.tb02081.x
Raes, F., Hermans, D., Williams, J. M. G., Beyers, W., Eelen, P., & Brunfaut, E. (2006). Reduced autobiographical memory specificity and rumination in predicting the course of depression. Journal of Abnormal Psychology, 115, 699-704. doi:10.1037/0021-843X.115.4.699
Rockliff, H., Karl, A., McEwan, K., Gilbert, J., Matos, M., & Gilbert, P. (2011). Effects of intranasal oxytocin on 'compassion focused imagery'. Emotion, 11, 1388-1396. doi:10.1037/a0023861
Romney, C., Hahn-Holbrook, J., Norman, G. J., Moore, A., & Holt-Lunstad, J. (2019). Where is the love? A double-blind, randomized study of the effects of intranasal oxytocin on stress regulation and aggression. International Journal of Psychophysiology, 136, 15-21. doi:10.1016/j.ijpsycho.2018.08.010
Schwaiger, M., Heinrichs, M., & Kumsta, R. (2019). Oxytocin administration and emotion recognition abilities in adults with a history of childhood adversity. Psychoneuroendocrinology, 99, 66-71. doi:10.1016/j.psyneuen.2018.08.025
Shamay-Tsoory, S. G., & Abu-Akel, A. (2016). The social salience hypothesis of oxytocin. Biological Psychiatry, 79, 194-202. doi:10.1016/j.biopsych.2015.07.020
Shamay-Tsoory, S. G., Fischer, M., Dvash, J., Harari, H., Perach-Bloom, N., & Levkovitz, Y. (2009). Intranasal administration of oxytocin increases envy and schadenfreude (gloating). Biological Psychiatry, 66, 864-870. doi:10.1016/j.biopsych.2009.06.009
Striepens, N., Kendrick, K. M., Hanking, V., Landgraf, R., Wullner, U., Maier, W., & Hurlemann, R. (2013). Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans. Scientific Reports, 3.
Striepens, N., Scheele, D., Kendrick, K. M., Becker, B., Schäfer, L., Schwalba, K., . . . Hurlemann, R. (2012). Oxytocin facilitates protective responses to aversive social stimuli in males. Proceedings of the National Academy of Sciences of the United States of America, 109, 18144-18149. doi:10.1073/pnas.1208852109
Tabak, B. A., Teed, A. R., Castle, E., Dutcher, J. M., Meyer, M. L., Bryan, R., . . . Eisenberger, N. I. (2019). Null results of oxytocin and vasopressin administration across a range of social cognitive and behavioral paradigms: Evidence from a randomized controlled trial. Psychoneuroendocrinology, 107, 124-132. doi:10.1016/j.psyneuen.2019.04.019
Weigand, A., Feeser, M., Gärtner, M., Brandt, E., Fan, Y., Fuge, P., . . . Grimm, S. (2013). Effects of intranasal oxytocin prior to encoding and retrieval on recognition memory. Psychopharmacology, 227, 321-329. doi:10.1007/s00213-012-2962-z
Williams, J. M. G., & Broadbent, K. (1986). Autobiographical memory in suicide attempters. Journal of Abnormal Psychology, 95, 144-149. doi:10.1037/0021-843X.95.2.144
Zhao, W., Luo, R., Sindermann, C., Li, J., Wei, Z., Zhang, Y., . . . Kendrick, K. M. (2020). Oxytocin modulation of self-referential processing is partly replicable and sensitive to oxytocin receptor genotype. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 96, 109734. doi:10.1016/j.pnpbp.2019.109734
Zhao, W., Yao, S. N., Li, Q., Geng, Y., Ma, X., Luo, L., . . . Kendrick, K. M. (2016). Oxytocin blurs the self-other distinction during trait judgments and reduces medial prefrontal cortex responses. Human Brain Mapping, 37, 2512-2527. doi:10.1002/hbm.23190
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