Login | Register

Computational investigation of weak-bonding interactions in substituted borane-ketone complexes

Title:

Computational investigation of weak-bonding interactions in substituted borane-ketone complexes

Archambault, Philippe (2015) Computational investigation of weak-bonding interactions in substituted borane-ketone complexes. Masters thesis, Concordia University.

[img]
Preview
Text (application/pdf)
Philippe Archambault - 25884071 - MSc Thesis-FINAL submission.pdf - Accepted Version
Available under License Spectrum Terms of Access.
6MB

Abstract

One of the largely unexplored areas of computational organic chemistry is the source of facial selectivity from prochiral ketones. Most of the available literature provides reaction pathways highlighting the lowest activation barrier, but this approach leaves the origin of the enantioselectivity unaddressed at the molecular level. Instead, the interactions that enable energetic differentiation in the transition states must be investigated for any useful information to be acquired for predictive purposes. The focus of this work is on the enantioselective CBS (Corey-Bakshi-Shibata) reduction as it has been extensively studied experimentally.
This work aims, first, to evaluate the complexation of substituted boranes with a prochiral ketone, acetophenone, for better understanding the modes of complexation during a reduction reaction, and second, to assess the source of facial selectivity of the enantioselective reduction of a different ketone, t-butyl methyl ketone, with borane using an oxazaborolidine catalyst. A systematic investigation of weak-bonding interactions in the complexes and their transition states is carried out computationally using electronic structure theory. A quantitative relationship between the electron demand on boron and the complexation energy is established from electron density analyses providing a binding cut-off of 0.19 e·Å^–3. In the CBS reduction of t-butyl methyl ketone, the calculated enantiomeric excess is 99 % or greater in favour of the R-configured product by transition state theory. The source of facial selectivity is uncovered through changes in features of the geometries and the electron densities as the responsible complexes as well as their transition states for hydride transfer are compared.

Divisions:Concordia University > Faculty of Arts and Science > Chemistry and Biochemistry
Item Type:Thesis (Masters)
Authors:Archambault, Philippe
Institution:Concordia University
Degree Name:M. Sc.
Program:Chemistry
Date:13 August 2015
Thesis Supervisor(s):Muchall, Heidi M.
ID Code:980311
Deposited By: PHILIPPE ARCHAMBAULT
Deposited On:03 Nov 2015 17:15
Last Modified:01 Sep 2018 00:00
All items in Spectrum are protected by copyright, with all rights reserved. The use of items is governed by Spectrum's terms of access.

Repository Staff Only: item control page

Downloads per month over past year

Back to top Back to top