Login | Register

Repetitive transcranial magnetic stimulation over dorsolateral prefrontal cortex modulates value-based learning during sequential decision-making

Title:

Repetitive transcranial magnetic stimulation over dorsolateral prefrontal cortex modulates value-based learning during sequential decision-making

Wittkuhn, Lennart, Eppinger, Ben, Bartsch, Lea M., Thurm, Franka, Korb, Franziska M. and Li, Shu-Chen (2017) Repetitive transcranial magnetic stimulation over dorsolateral prefrontal cortex modulates value-based learning during sequential decision-making. NeuroImage . ISSN 10538119 (In Press)

[img]
Preview
Text (application/pdf)
eppinger-neuroimage-2017.pdf
Available under License Spectrum Terms of Access.
1MB

Official URL: http://dx.doi.org/10.1016/j.neuroimage.2017.11.057

Abstract

Adaptive behavior in daily life often requires the ability to acquire and represent sequential contingencies between actions and the associated outcomes. Although accumulating evidence implicates the role of dorsolateral prefrontal cortex (dlPFC) in complex value-based learning and decision-making, direct evidence for involvements of this region in integrating information across sequential decision states is still scarce. Using a 3-stage deterministic Markov decision task, here we applied offline, inhibitory low-frequency 1-Hz repetitive transcranial magnetic stimulation (rTMS) over the left dlPFC in young male adults (n = 31, mean age = 23.8 years, SD = 2.5 years) in a within-subject cross-over design to study the roles of this region in influencing value-based sequential decision-making. In two separate sessions, each participant received 1-Hz rTMS stimulation either over the left dlPFC or over the vertex. The results showed that transiently inhibiting the left dlPFC impaired choice accuracy, particularly in situations in which the acquisition of sequential transitions between decision states and temporally lagged action-outcome contingencies played a greater role. Estimating parameters of a diffusion model from behavioral choices, we found that the diffusion drift rate, which reflects the efficiency of information integration, was attenuated by the stimulation. Moreover, the effects of rTMS interacted with session: individuals who could not efficiently integrate information across sequential states in the first session due to disrupted dlPFC function also could not catch up in performance during the second session with those individuals who could learn sequential transitions with intact dlPFC function in the first session. Taken together, our findings suggest that the left dlPFC is crucially involved in the acquisition of complex sequential relations and in the potential of such learning.

Divisions:Concordia University > Faculty of Arts and Science > Psychology
Item Type:Article
Refereed:Yes
Authors:Wittkuhn, Lennart and Eppinger, Ben and Bartsch, Lea M. and Thurm, Franka and Korb, Franziska M. and Li, Shu-Chen
Journal or Publication:NeuroImage
Date:2 December 2017
Digital Object Identifier (DOI):10.1016/j.neuroimage.2017.11.057
ID Code:983288
Deposited By: DANIELLE DENNIE
Deposited On:08 Dec 2017 21:45
Last Modified:01 Dec 2018 01:01
All items in Spectrum are protected by copyright, with all rights reserved. The use of items is governed by Spectrum's terms of access.

Repository Staff Only: item control page

Downloads per month over past year

Back to top Back to top