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Use of Cognitive Strategies in Rats: the Role of Estradiol and its Interaction with Dopamine

Title:

Use of Cognitive Strategies in Rats: the Role of Estradiol and its Interaction with Dopamine

Quinlan, Matthew G. and Hussain, Dema and Brake, Wayne G. (2008) Use of Cognitive Strategies in Rats: the Role of Estradiol and its Interaction with Dopamine. Hormones and Behavior , 53 (1). 185 -191. ISSN 0018-506X

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Official URL: http://dx.doi.org/10.1016/j.yhbeh.2007.09.015

Abstract

Accumulating evidence suggests a role for estrogen in the use of a particular cognitive strategy when solving a maze task. In order to confirm the role of estrogen in this phenomenon, ovariectomized (OVX) female rats receiving either high (~ 90 pg/ml) or low (~ 32 pg/ml) circulating levels of 17β-estradiol benzoate (E2) performed a plus maze task for a reward. Consistent with previous research, OVX rats receiving low levels of E2 utilized a striatum-mediated response strategy while OVX rats administered high levels of E2 employed a hippocampus-mediated place strategy. Furthermore, following a systemic injection of a moderate dose of either a dopamine D1 (SKF 83566, 0.1 mg/kg IP) or D2 (raclopride, 0.5 mg/kg IP) receptor antagonist, low E2 rats were seen to use the opposite strategy and exercise a hippocampus-mediated place strategy in order to obtain the reward. At the same doses, high E2 rats did not change from using a place strategy. At a lower dose, these drugs shifted high E2 rats such that they showed an equal propensity for either strategy; this was not observed in low E2 rats. These results corroborate previous findings that E2 plays a significant role in the use of either a response or place strategy when solving a maze for a reward. In addition, the shift in strategy after dopamine receptor blockade implies the importance of central dopamine function in selecting a cognitive strategy to solve such tasks. It is suggested that estrogen alters cognitive strategy not only by improving hippocampal function, but also by altering dopamine-regulated striatal function.

Divisions:Concordia University > Faculty of Arts and Science > Psychology
Item Type:Article
Refereed:Yes
Authors:Quinlan, Matthew G. and Hussain, Dema and Brake, Wayne G.
Journal or Publication:Hormones and Behavior
Date:January 2008
Funders:
  • Natural Sciences and Engineering Research Council of Canada (NSERC)
  • Canada Foundation for Innovation (CFI)
Keywords:Cognitive strategy, response learning, memory, SKF 83566, raclopride, plus maze
ID Code:6331
Deposited By:KUMIKO VEZINA
Deposited On:09 Sep 2009 16:52
Last Modified:08 Dec 2010 18:58
Related URLs:
References:
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