Guo, Tong and Kit, Yuriy Y. and Nicaud, Jean-Marc and Le Dall, Marie-Thérèse and Sears, S. Kelly and Vali, Hojatollah and Chan, Honey and Rachubinski, Richard A. and Titorenko, Vladimir I. (2003) Peroxisome division in the yeast Yarrowia lipolytica is regulated by a signal from inside the peroxisome. The Journal of Cell Biology, 162 (7). pp. 1255-1266. ISSN 0021-9525
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Official URL: http://dx.doi.org/10.1083/jcb.200305055
We describe an unusual mechanism for organelle division. In the yeast Yarrowia lipolytica, only mature peroxisomes contain the complete set of matrix proteins. These mature peroxisomes assemble from several immature peroxisomal vesicles in a multistep pathway. The stepwise import of distinct subsets of matrix proteins into different immature intermediates along the pathway causes the redistribution of a peroxisomal protein, acyl-CoA oxidase (Aox), from the matrix to the membrane. A significant redistribution of Aox occurs only in mature peroxisomes. Inside mature peroxisomes, the membrane-bound pool of Aox interacts with Pex16p, a membrane-associated protein that negatively regulates the division of early intermediates in the pathway. This interaction inhibits the negative action of Pex16p, thereby allowing mature peroxisomes to divide.
|Divisions:||Concordia University > Faculty of Arts and Science > Biology|
|Authors:||Guo, Tong and Kit, Yuriy Y. and Nicaud, Jean-Marc and Le Dall, Marie-Thérèse and Sears, S. Kelly and Vali, Hojatollah and Chan, Honey and Rachubinski, Richard A. and Titorenko, Vladimir I.|
|Journal or Publication:||The Journal of Cell Biology|
|Date:||22 September 2003|
|Deposited By:||DANIELLE DENNIE|
|Deposited On:||11 May 2011 12:50|
|Last Modified:||11 May 2011 12:50|
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